Role of Heat Shock Protein – 70 in the etiology of Idiopathic Pulmonary Arterial Hypertension
Journal Title: International Journal of Life Science - Year 2016, Vol 4, Issue 4
Abstract
Idiopathic Pulmonary Arterial Hypertension is a rare disorder that affects the pulmonary artery, whereby the pressure in the pulmonary artery is increased, culminating in overload on the right ventricle and eventually heart failure. Over the years many studies have been carried out to understand the etiology and to identify the appropriate treatment. This study attempts to contribute to the overall understanding of disease in relation with certain genes that are generally expressed under stress conditions, viz., the heat shock proteins (HSPs). Of this, a prominent group of proteins, HSP70, were identified, to establish a correlation with polymorphisms in these genes and any possible effect on IPAH.
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