ROLE OF HIGH MOBILITY GROUP CHROMOSOMAL PROTEIN 1 AND CLUSTERIN AS MARKERS IN PATIENTS WITH HEPATITIS C VIRUS RELATED HEPATOCELLULAR CARCINOMA
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2017, Vol 2, Issue 6
Abstract
CLUSTERIN is A highly conserved heterodimeric disulde-linked 80K glyco- protein originally named apolipoprotein-J (ApoJ) , which is widely distributed in tissues and body uids. In 1983 identied a high-molecular weight protein in ram rete testis uid and named Clusterin CLU because it is a cell-aggregating factor capable of eliciting the “Clustering” of Sertoli cells . In humans, it was rstly puried from serum and the cloned gene was named CLI (complement cytolysis inhibitor) or ApoJ due to similarities with other known. It consists of two polypeptide chains connected by four to ve disulde bonds.
Authors and Affiliations
Mahmoud Mahmoud M. Abu-Elanien Khattab, Fatma Alzahraa Sayed Bukhary, Mohamed Alsayed Abd -Alaal Shatat, Lamiaa Hamdy Aly, Fatma Mokhtar Saban
Keywords
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