Role of Human Papilloma Virus in Oral Squamous Cell Carcinoma: Review Article
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 2
Abstract
Oral cancer etiology is multifactorial and the main risk factors are tobacco chewing and smoking along with alcohol consumption. 10% to 20% of population do not have any habits and are still diagnosed with oral cancer. This suggest the role of other factors, including viruses like Human papilloma virus (HPV) in oral carcinogenesis. Human papilloma virus is considered as a prime suspect in the etiology of oral squamous cell carcinoma (OSCC) due to their ability to immortalize oral keratinocytes and bring about transformation of epithelial cells. Molecular classification of tumors thus provides important new information which allows better estimate of prognosis and use of targeted therapy
Authors and Affiliations
Sreejyothi H K, Harishchandra Rai, Shreedevi B, Harikrishnan H K
Keywords
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