Role of Magnesium as Analgesic Sparing Adjuvant to Ropivacaine in Thoracic Paravertebral Block for Breast Cancer Surgery: A Prospective, Double-Blinded Randomised Controlled Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 12
Abstract
ABSTRACT Introduction: Thoracic surgeries are often associated with intractable pain leading to postoperative pulmonary complications. To alleviate this pain in intraoperative and postoperative period, Thoracic Paravertebral Block (TPVB) has been proven as an effective mean. Various adjuvants and their mixtures have been tried to prolong the duration of TPVB. Aim: In this randomised controlled study, we have evaluated the analgesic sparing efficacy of magnesium sulfate; a NMDA receptor antagonist, administered along with ropivacaine for TPVB for breast cancer surgery patients. Materials and Methods: Eighty breast cancer surgery patients, undergoing General Anaesthesia (GA), were randomly divided into group RP and group RM (n=40 each) receiving preoperative TPVB at T3-5 level with 0.5% ropivacaine solution admixture with normal saline and magnesium sulphate, respectively. Intraoperative fentanyl and propofol requirement was compared. Visual Analogue Scale (VAS) was used for postoperative pain assessment. Total dose and mean time to administration of first rescue analgesic paracetamol was noted. Side effects and haemodynamic parameters were also noted. Results: Intraoperative fentanyl (153.86 vs. 138.49 μg), propofol requirement (150.34 vs. 134.23 mg) was significantly less in test (magnesium) group. The requirement of paracetamol was also significantly less (1592.09 vs. 1149.23 mg) and later (8.44 vs. 13.34 hour) in group RM than group RP. Haemodynamics and side effects were comparable among two groups. Conclusion: Magnesium provided better intraoperative as well as postoperative analgesia than placebo when administered with ropivacaine in TPVB prior to breast cancer surgery patients. It also renders a lesser analgesic requirement without major haemodynamic alteration and side effects.
Authors and Affiliations
Sandip Roybasunia, Anjan Das, Tapo brata Mitra, Nairitata Mayur, Hirak Biswas, Anindya Mukherjee, Chiranjib Bhattacharyya, Subrata Mandal
Keywords
Related Articles
- EP ID EP526366
- DOI 10.7860/JCDR/2018/38012.12348
- Views 71
- Downloads 0
Regulation of Molecular Diagnostic (NAT) Kits For HBV, HCV and HIV in India
Letter to Editor
Effect of Inspiratory Muscle Training and Diaphragmatic Breathing Exercises on Dyspnea, Pulmonary Functions, Fatigue and Functional Capacity in Pregnancy during Third Trimester
ABSTRACT Introduction: Pregnancy induces various physical and psychological alterations that cause dyspnea, reduced exercise capacity, fatigue, anxiety, altered pulmonary functions, nausea and vomiting. These alterations...
Acute Total Lung Collapse in a Woman with Acute Stroke and Atrial Fibrillation
Images in Medicine
Comparative Evaluation of Colony Forming Units of Candida After Using Plain and Probiotic Added Denture Adhesive in Completely Edentulous Patients: A Randomised Crossover Trial
Abstract Introduction: Completely edentulous patients who wear dentures are more prone to candidiasis, under certain special conditions like compromised immunity. Besides that, if denture adhesives are also being used an...
A Six Year Trend in Treatment Outcomes among Tuberculosis Patients and its Determinants in Andaman and Nicobar Islands
ABSTRACT Introduction: Directly Observed Treatment Short (DOTS) course strategy is aimed at diagnosing 70% of infectious Tuberculosis (TB) and curing 85% of it. Aim: To analyse the trend in TB treatment outcomes in the n...