Role of Micronutrients -“Selenium & Zinc” in Preeclampsia
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 4
Abstract
Background: Micronutrients are vitamins and minerals required in minute amounts for normal functioning, growth and development. Adequate maternal micronutrient status is especially vital during pregnancy and lactation. Micronutrient deficiencies are exacerbated in pregnancy, leading to potential adverse effects not only on the mother but also on fetus. Therefore, micronutrient status plays an important role in pregnancy and birth outcomes. Deficiencies of specific antioxidant activities associated with the micronutrients like Selenium and Zinc can result in poor pregnancy outcomes, including fetal growth restriction, preeclampsia and the associated increased risk of diseases in adulthood, including cardiovascular disease and type 2Diabetes. Aim: To asses the status of Selenium & Zinc in preeclamptic women. Objective: To prove Selenium & Zinc deficiencies as contributory factors for the onset of preeclampsia.. Data Sources: This is a prospective study done in the Department of Obstetrics and Gynaecology, Narayana Medical College & Hospital, Nellore for a period of 2yrs (October 2012 –October 2014).100 preeclamptic women, are recruited into the study (Study group). A similar number (100) of healthy pregnant women were taken as controls(Control group). Methodology: Serum and tissue (Placenta) samples for SE and Zn are measured by atomic absorption spectrophotometry. The Statistical software namely SPSS 20.0 were used for the analysis. Results: The mean serum & tissue SE and Zn levels are found to be significantly reduced in preeclamptic cases compared to controls. Conclusions: Selenium and zinc supplementation either alone or in combination with a general multi-nutrient supplement may have a significant effect not only on the incidence of preeclampsia, but may also delay the onset and severity of the disease, ameliorating placental oxidative stress and buying valuable time for fetal development prior to delivery.
Authors and Affiliations
Prof. Dr. Kaliki Hymavathi Reddy
Keywords
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