Role of nanoparticles in elimination of biofilm produced by pathogenic bacteria
Journal Title: Journal of Contemporary Pharmacy - Year 2022, Vol 6, Issue 1
Abstract
Biofilm is a structured conglomeration of bacteria entrenched in a polymer matrix that is self-produced and contains DNA, polysaccharide, protein, and cause chronic infections. Pseudomonas aeruginosa lung infection is one of the well stated examples of pathogenic biofilms in cystic fibrosis patients. Due to mutating nature of the pathogens high antibiotic resistance will develop that make antibiotic treatment ineffective against repeated infections that are related to indwelling medical devices. Normally it was considered that nanoparticles are not larger than 100 nm, and their development to fight infection has gained popularity over the several decades. Different types of nanoparticles were introduced to treat biofilm infections in which silver nanoparticles were considered to be more efficient than all others. Maximum zone of inhibition in case of silver nanoparticles was found to be 40 mm against S.aureus, whereas maximum zone of inhibition with ZnO nanoparticles was 16 mm against Campylobacter jejuni, while in case of selenium nanoparticles and iron oxide nanoparticles zone of inhibition was time dependent and concentration dependent respectively. The order of antibacterial activity was like that Ag-Np>ZnO>CuO>Fe2O3. In this review article we discussed different biofilm producing pathogens that were isolated from different locations in latest research and to evaluate the role of nanoparticles in eradicating these pathogenic microbes.
Authors and Affiliations
Samina Kousar, Atia Iqbal, Shafqat Rasool, Hafiz M. N. Iqbal
Keywords
Related Articles
- EP ID EP713757
- DOI https://doi.org/10.56770/jcp2022614
- Views 64
- Downloads 0
Formulation development and characterization of famotidine dry suspension for oral use
Famotidine an H2 receptor blocker is generally used to treat ulcers of stomach and intestine. Famotidine is available in liquid suspension that is unstable during shelf life. Degradation of the drug as well as bad smell...
Extraction and comparison of quality and purity of DNA of medicinal plants by CTAB and kit method
Background: Today is a world of bioengineering. Man is playing with DNA. Extraction and isolation of DNA has become as a key part for the researches of modern times. One needs high quality and increased quantity of DNA f...
Gastroretentive floating microspheres for the management hypertension based on drug combination of amlodipine /losartan
Background: Hypertension is one of the serious global health issues that affect millions of people and leads to cardiovascular damage if remain untreated. Various antihypertensive drugs have been developed but it is diff...
Tuberculosis in geriatric patients
Tuberculosis is developing as a noteworthy medical problem in geriatrics. The indications are frequently nonparticular and prompt postponed finding. Propelled infection state exhibit at the time of determination and regu...
Formulation and evaluation of sustained release domperidone hydrochloride transdermal patches to treat motion sickness
Objective: Transdermal route of drug delivery is superior than oral route because it avoids first pass effect, ensures better patient compliance, reduce dosing frequency especially in extended-release formulation and is...