Role of Omega-3 Fatty Acids on Lipid Profile in Diabetic Dyslipidaemia: Single Blind, Randomised Clinical Tria
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 3
Abstract
Introduction: Diabetic dyslipidaemia is characterised by hypertriglyceridaemia, low High Density Lipoprotein (HDL), postprandial lipaemia, small and dense LDL particles is considered to be a major predisposing factor for various macrovascular complications. Omega-3 fatty acids are fish oil derivative introduced in the market for dyslipidaemia associated with increased triglyceride level. Aim: To study the effect of omega-3 fatty acids on lipid profile in Type II diabetes patients. Materials and Methods: This study was prospective, single blind, randomized comparative trial. Hundred patients were randomized into three groups. Group I received metformin 500 mg twice daily and placebo, Group II received metformin 500 mg twice daily and omega-3 fatty acids (1 gram) once daily and the Group III received metformin 500 mg twice daily and omega-3 fatty acids (1 gram) twice daily. ANOVA test was applied for analysis. Results: Group II was effective in reducing the triglyceride level from 144.59±14.18 mg/dl to 101±13.31 mg/dl which was significant as compared to Group I from 147.67±18.57 mg/dl to 145.8±19.86 mg/dl respectively. Group III containing 1 g of omega-3 fatty acids twice daily showed decrease from 144.83±22.17 mg/dl to 86±17.46 mg/dl and was more effective in reducing triglyceride levels than Group II containing 1 gram of omega-3 fatty acids once daily. Conclusion: Omega-3 fatty acids can be given in conjunction with metformin to reduce triglyceride levels in diabetic dyslipidaemia without any adverse drug reactions or any drug interaction. Omega-3 fatty acids were effective in reducing the triglyceride level significantly as compared to placebo. Two grams of omega-3 fatty acids were more effective than 1 gram of omega-3 fatty acids in reducing triglyceride levels.
Authors and Affiliations
Shaylika Chauhan, Hanish Kodali, Jawad Noor, Karuna Ramteke, Vidisha Gawai
Keywords
Related Articles
- EP ID EP335389
- DOI 10.7860/JCDR/2017/20628.9449
- Views 96
- Downloads 0
A Rare Cause of Ophthalmia Neonatorum-Achromobacter denitrificans
ABSTRACT A 72-hour-old neonate presented with lethargy and eye discharge. Keratitis and corneal ulceration was present on the left side. Work up revealed early onset sepsis with meningitis and keratoconjunctivitis. A ra...
Nucleic Acid Amplification Testing Detects HIV Transmission Risk in Serologically-Tested Blood Donor Units
ABSTRACT Introduction: Blood transfusion is an essential life-saving intervention in the healthcare delivery. Mandatory screening of donor units helps prevent transfusion-transmissible infections, such as Human Immunodef...
Comparison of Methods to Assay Liver Glycogen Fractions: The Effects of Starvation
Introduction: There are several methods to extract and measure glycogen in animal tissues. Glycogen is extracted with or without homogenization by using cold Perchloric Acid (PCA). Aim: Three procedures were compared to...
All about Dowels - A Review Part I. Considerations before Cementation
The optimal way of restoring a non vital tooth with dowel-core technique has long been a controversial matter. The purpose of this review was to assess the factors that may influence the successful restoration of root fi...
Esthesioneuroblastoma Presenting with Bilateral Proptosis and Blindness in a Child: A Case Report
Esthesioneuroblastoma is a rare malignant tumour of the olfactory epithelium. The most common symptom is related to unilateral nasal obstruction. It rarely presents with bilateral proptosis and blindness. We report a 21-...