Role of patch testing in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in a tertiary centre in North Kerala, India
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 5
Abstract
Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are life threatening disorders mainly due to drugs. Patch testing is useful in identifying the drug as a cause. Objectives: To confirm the drug as the causative agent for SJS and TEN by patch testing in selected cases. Materials and Methods A 2 year study of patients presenting with SJS and TEN was carried out. A detailed examination to know the cutaneous and mucosal involvement was done. Biopsy was done in 3 patients and patch testing in 8 patients who were willing. Results There were fifty patients of SJS-TEN spectrum. Of which 31 were SJS, 3 had SJS-TEN overlap and 16 had TEN. Anticonvulsants were implicated in causing these reactions in 24 patients (48%) with carbamazepine being the most commonest i.e.in 16 patients (32%). Three patients with TEN (6%) died. Patch testing was negative for the drug implicated in all the 8 cases. Conclusion To conclude, TEN was less commoner than SJS, had more sequelae and more mortality compared to SJS. Mortality was lower compared to other studies. Patch testing had no role in our study in identifying the implicated drug.
Authors and Affiliations
Dr. RAHIM S
Keywords
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Role of patch testing in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in a tertiary centre in North Kerala, India
Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are life threatening disorders mainly due to drugs. Patch testing is useful in identifying the drug as a cause. Objectives: To confirm the drug as the c...