Role of PPAR Gamma in obesity and obesity induced DM type-2
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 3
Abstract
PPAR-γ plays a critical role in glucose homeostasis and is a molecular target of insulin sensitizing drugs called thiazolidinediones which are PPAR-γ ligands (3). PPAR-γ ligands also upregulate expression of adipocyte glycerol kinase, resulting into improved insulin action in target tissue such as liver and muscle (4). PPAR-γ ligand also shown to augment glucose disposal in peripheral tissues by increasing expressions of the glucose transporter genes, GLUT-1 and GLUT-4 (5Majority of the Diabetes Mellitus Type 2 (DM type 2) patients (80%) are obese, but all obese persons do not develop DM type 2. Serum adiponectin level should be determined by level of PPAR-γ activity in adipocytes. Therefore it will be of interest to explore the difference in the level of serum PPAR-γ level between obese subjects with DM-2 and without DM-2, as both the insulin sensitizing factor’s adiponectin, and vistafin are synthesized in response to FFA. PPAR-γ complex receptor activity. Estimation of serum PPAR- level alongwith FBG was done in 90 cases, of which 30 were normal healthy subjects, 30 obese without diabetes type 2 and 30 obese with diabetes type 2 . The qualitative estimation of PPAR-γ in human serum was done by ELISA method using ELISA kit from E lab science Biotechnology co.ltd. In our study we found a significant change in the level of PPAR- between the obese with DM-2 and control subject and also between obese without DM-2 and control subject but we did not find any significant difference between obese with DM-2 and obese without DM-2 In our present study we found the Increased Levels of PPAR- in the Obese without Diabetes Mellitus and Obese with Diabetes Mellitus. The levels were 8.03ng/ml ±11.16 and 8.04ng/ml±10.94 respectively. Finally, we observed that the level of PPAR- is increased with both the groups,i.e .obese without DM-2 and obese with DM-2 in comparison to normal subjects.
Authors and Affiliations
Manish Malhotra
Keywords
Related Articles
- EP ID EP209427
- DOI -
- Views 116
- Downloads 0
Clinical Presentation & Management of hydro pneumothorax (Broncho Pleaural Fistula) (B.P.F.)
Introduction: Hydropneumothorax is an abnormal presence of air and fluid in pleural space. Aim: To Study signs and symptoms, causes & treatment modalities for hydropneumothorax. Materials & Method: Patients admitted from...
Histopathological Study of Cholecystectomy Specimens in Tertiary Care Centre - Two Year Study
Background: Gallbladder stones are commonest disorder among gall bladder lesions and are usually asymptomatic. Its frequency in cholecystectomy specimens is not clear. The aim of this study is to report the morphological...
An Evaluation of the Needs among Differently Abled Population
Objectives: The study evaluated the needs of the differently-abled population from the society, the government on their problems on jobs placement and the perception of their physical challenges, Kanchipuram District, So...
Role of Molecular Markers (P53, EGFR AND VEGF) in Prognostication of Carcinoma Rectum
Colorectal cancer is the third most common cancer worldwide. Surgery remains the primary determinant of cure in patients with localized rectal cancer and for patients with invasive tumors neo-adjuvant chemoradiotherapy h...
Primary Multidrug Resistant Tuberculosis Involving Unique Extra Pulmonary Site
Prevalence of MDR among patients of extra pulmonary tuberculosis is less than 3% in Indian population. Isolated primary MDR tuberculosis of knee is rarely reported. We report a case of isolated primary MDR tuberculosis o...