Role of PPAR Gamma in obesity and obesity induced DM type-2
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 3
Abstract
PPAR-γ plays a critical role in glucose homeostasis and is a molecular target of insulin sensitizing drugs called thiazolidinediones which are PPAR-γ ligands (3). PPAR-γ ligands also upregulate expression of adipocyte glycerol kinase, resulting into improved insulin action in target tissue such as liver and muscle (4). PPAR-γ ligand also shown to augment glucose disposal in peripheral tissues by increasing expressions of the glucose transporter genes, GLUT-1 and GLUT-4 (5Majority of the Diabetes Mellitus Type 2 (DM type 2) patients (80%) are obese, but all obese persons do not develop DM type 2. Serum adiponectin level should be determined by level of PPAR-γ activity in adipocytes. Therefore it will be of interest to explore the difference in the level of serum PPAR-γ level between obese subjects with DM-2 and without DM-2, as both the insulin sensitizing factor’s adiponectin, and vistafin are synthesized in response to FFA. PPAR-γ complex receptor activity. Estimation of serum PPAR- level alongwith FBG was done in 90 cases, of which 30 were normal healthy subjects, 30 obese without diabetes type 2 and 30 obese with diabetes type 2 . The qualitative estimation of PPAR-γ in human serum was done by ELISA method using ELISA kit from E lab science Biotechnology co.ltd. In our study we found a significant change in the level of PPAR- between the obese with DM-2 and control subject and also between obese without DM-2 and control subject but we did not find any significant difference between obese with DM-2 and obese without DM-2 In our present study we found the Increased Levels of PPAR- in the Obese without Diabetes Mellitus and Obese with Diabetes Mellitus. The levels were 8.03ng/ml ±11.16 and 8.04ng/ml±10.94 respectively. Finally, we observed that the level of PPAR- is increased with both the groups,i.e .obese without DM-2 and obese with DM-2 in comparison to normal subjects.
Authors and Affiliations
Manish Malhotra
Keywords
Related Articles
- EP ID EP209427
- DOI -
- Views 109
- Downloads 0
Stenotrophomonas Maltophilia- A Rare Cause of Prosthetic Valve Endocarditis: A Case Report and Review of Literature
Background: Stenotrophomonas maltophilia (S. Maltophilia) is a gram-negative bacillus presumed to be a commensal and rarely causes opportunistic infections in immunocompromised individuals. Since it is resistant to most...
Estimation of Serum Lipids in Colorectal Carcinoma: A Prospective Study
To investigate the correlation between lipid metabolism disorder and the occurrence and development of colorectal cancer by monitoring the alteration in lipid levels in cancerous tissue and serum in patient with colo rec...
A Cross-sectional Study on Age related Dyslipidaemia in patients with Type2 Diabetes mellitus
Objectives: This study was to evaluate the effect of duration of diabetes mellitus on lipid profile of different age groups patients, establish the relation between serums lipid profile of patients with type 2 Diabetes m...
Uterine Electrical Activity During First Stage of Labor
Palpation tecnique still used today, studies have shown that this technique is uneffective for measuring uterine contractions during labor. Electromyogram (EMG) with surface electrodes is a non-invasive tool that can be...
Efficacy of Spinal Manipulation as a Part of Physical Therapy Program in Patients with Lumbar Disc Herniation: A Randomized Controlled Trial
Objective: To investigate the effect of a combined spinal manipulation plus physical therapy program on pain intensity, physical function and asymmetry of lumbar facet angles in patients with lumbar disc herniation. Meth...