Role of protein disulfide isomerase in activation of integrins

Apply

Role of protein disulfide isomerase in activation of integrins

Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue

Abstract

Integrins belong to a large family of transmembrane cell adhesion receptors that communicate biochemical and mechanical signals in a bidirectional manner across the plasma membrane. Integrins and their ligands play a crucial role in a number of physiological and pathological processes, including cell migration, cell differentiation, hemostasis, adhesion, angiogenesis, cancer, cell invasiveness and wound healing. Intracellular signals switch integrins into a ligand-competent state as a result of conformational changes within the integrin molecule. Binding of extracellular ligands induces structural changes that can transmit signals to the cell interior. Transition of integrins from an inactive to a ligand binding state involves rearrangement of the disulfide bonding pattern. The rearrangement of disulfide bonds is modulated by protein disulfide isomerase (PDI). PDI has been found on the surface of several types of cells, including endothelial cells, hepatocytes, cancer cells, pancreatic cells and B cells. PDI was identified on the platelet surface, where it plays an important role in platelet reactions such as adhesion, aggregation and secretion. PDI was found to directly interact with integrins. Disulfide-thiol exchange mediated by PDI appears to be involved in the conformational changes in integrin activation. In this report we describe the structure of integrin and the role of disulfide bond rearrangement in its activation.

Authors and Affiliations

Marcin Popielarski, Halszka Ponamarczuk, Katarzyna Sobierajska, Maria Świątkowska

Keywords

Integrins PDI Thiol groups disulfide bonds redox state Ero1 reduction-oxidation

Neuropeptydy Y, YY i PP oraz ich znaczenie kliniczne

Neuropeptydy są białkowymi molekułami należącymi do klasy informatorów zarówno dlaośrodkowego, jak i obwodowego układu nerwowego. Biorąc pod uwagę budowę i pochodzenieewolucyjne, neuropeptyd Y (NPY) należy do tej samej r...

Udział czynników genetycznych (polimorfizm PON1) i środowiskowych, a zwłaszcza aktywności fizycznej, w procesie antyoksydacyjnego działania paraoksynazy

Paraoksonaza 1 (PON1) należy do trójgenowej rodziny enzymów (PON1, PON2 i PON3). W osoczu człowieka dominuje aktywność PON1. Enzym ten wydzielany jest przez hepatocyty wątroby do krwi, gdzie wiąże się z lipoproteiną o du...

EP ID EP67390
DOI -
Views 115
Downloads 0