Role of Red Cell Distribution Width in Evaluation of Inflammatory Bowel Disease Activity
Journal Title: Journal of Academic Research in Medicine - Year 2020, Vol 10, Issue 3
Abstract
Objective: We aimed to determine whether red cell distribution width (RDW) is useful in evaluating the activity and remission periods of inflammatory bowel disease (IBD). Methods: One hundred thirty-two IBD patients, consisting of 98 ulcerative colitis (UC) patients and 34 Crohn’s patients, were included in this retrospective study. Serum C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), leukocyte and platelet counts and hemoglobin (Hb) concentrations were evaluated separately during disease activity and remission periods. Disease activity for UC and Crohn’s disease was determined by Mayo score and Crohn’s Disease Activity Index (CDAI), respectively. Results: The median age (interquartile range) was 37.5 (29-50) and the duration of the disease was 29.4±44.3 months in the patients included in the study. RDW, ESR, CRP values, leukocyte and thrombocyte counts were significantly active periods compared to remission periods (p<0.01), while Hb concentration was significantly lower (p<0.001). ESR, CRP, and platelet levels were significantly associated with Mayo score in UC patients and CDAI severity in Crohn’s patients (p<0.05). No association was observed between RDW and disease severity according to IBD activity scores. RDW, ESR, CRP values and platelet counts were significantly higher during the active periods of patients with UC (36.7%) and Crohn’s disease (41.2%) with anemia than those without anemia (p<0.01). Conclusion: RDW can be used as an indicator of activity and remission in IBD patients. RDW can be a useful additional marker as an easy and inexpensive tool to monitor disease activity, predict relapse, and follow-up treatment.
Authors and Affiliations
Deniz Öğütmen Koç, Murat Keğin
Keywords
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- EP ID EP691756
- DOI 10.4274/jarem.galenos.2020.3453
- Views 96
- Downloads 0
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