Role of reverse pharmacognosy in finding lead molecules from nature
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 4
Abstract
Alternative systems of medicine viz. Ayurveda, Siddha and traditional system of Medicine have become more popular in recent years and have proven their significance in medical sciences [1]. Combining the strength of knowledge based on traditional systems such as Ayurveda with the dramatic power of combinatorial sciences and high-throughput screening (HTS) will help in the generation of structure activity libraries. The three main hurdles in the drug development to provide new functional leads are time, money and toxicity which can be reduced by traditional knowledge and experimental database [3]. High-throughput screening (HTS) for biological testing and combinatorial chemistry to generate potential hits are the various efforts to accelerate and rationalize drug discovery, but these techniques have not able to increase the discovery of new herbal molecules that are active in vivo [4]. Pharmacognosy, ethno pharmacology and phytochemistry are various branches which have contributed to the discovery of new biologically active natural entities [5]. Many studies have been done which favor integrating traditional knowledge into user friendly databases help the early drug discovery stages [6]. The review will focus on the technique used in reverse Pharmacognosy along with its importance in natural drug discovery to finding out a lead molecule from the natural source.
Authors and Affiliations
Diptanu Biswas
Keywords
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