Role of reverse pharmacognosy in finding lead molecules from nature
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 4
Abstract
Alternative systems of medicine viz. Ayurveda, Siddha and traditional system of Medicine have become more popular in recent years and have proven their significance in medical sciences [1]. Combining the strength of knowledge based on traditional systems such as Ayurveda with the dramatic power of combinatorial sciences and high-throughput screening (HTS) will help in the generation of structure activity libraries. The three main hurdles in the drug development to provide new functional leads are time, money and toxicity which can be reduced by traditional knowledge and experimental database [3]. High-throughput screening (HTS) for biological testing and combinatorial chemistry to generate potential hits are the various efforts to accelerate and rationalize drug discovery, but these techniques have not able to increase the discovery of new herbal molecules that are active in vivo [4]. Pharmacognosy, ethno pharmacology and phytochemistry are various branches which have contributed to the discovery of new biologically active natural entities [5]. Many studies have been done which favor integrating traditional knowledge into user friendly databases help the early drug discovery stages [6]. The review will focus on the technique used in reverse Pharmacognosy along with its importance in natural drug discovery to finding out a lead molecule from the natural source.
Authors and Affiliations
Diptanu Biswas
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Carbon nanotubes are fullerene-related structures which consist of graphene cylinders closed at either end with caps containing pentagonal rings. This is a nanoscopic structure made of carbon atoms in the shape of a ho...
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Chronotherapeutic drug delivery system is useful in the treatment of disease, in which drug availability is timed to match rhythm of disease, in order to optimize therapeutic effect and minimize side effect. Nocturnal...
Phytochemical evaluation of Mussaenda erythrophylla, Elaeocarpus ganitrus, Cassia sophera
In the present study, an attempt was made to investigate Phytochemical evaluation of roots of Mussaenda erythrophylla, Elaeocarpus ganitrus and Cassia sophera. The crude drug powder extracts of the above plants were ta...
The study of antihyperglycaemic activity of aqueous extract of root of Cleome chelidonii herb in rats
The work was aimed to explore the hypoglycaemic and antihyperglycaemic activity of aqueous extract of root of Cleome chelidonii herb. The extract was evaluated for its specific physical and chemical characteristics in...