Role of Surfactant by INSURE Approach in Management of Preterms with Respiratory Distress Syndrome
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 2
Abstract
Surfactant replacement therapy by ‘INSURE’ is a gentle ventilatory approach in preterms with Respiratory Distress Syndrome (RDS) reducing the mortality and is associated with less adverse sequelae than mechanical ventilation. The objective of the present study is to determine the role of surfactant therapy by INSURE in reducing the mortality of preterms with RDS. 59 preterm babies with RDS were included in the study. 32 were given surfactant. 27 preterm infants who could not afford to purchase surfactant were taken as controls. There is statistically significant difference in mortality between two groups (31.5% vs 63%). The commonest cause of death in study group was sepsis (40%) and in control group was respiratory failure (41%). The mean duration of oxygen therapy, CPAP and mechanical ventilation was much less in the study group than in the control group. This study shows that INSURE is safe and cost effective intervention in reducing the mortality and need for mechanical ventilation in preterm infants with RDS. Keywords: Respiratory distress syndrome (RDS), nCPAP, Mechanical ventilation, surfactant, INSURE, DOWNE’S score.
Authors and Affiliations
N. Madhavi, D. Manikyamba, M. Jhancy, A. Satyavani, K. T. V. Lakshman Kumar
Keywords
Related Articles
- EP ID EP372947
- DOI -
- Views 73
- Downloads 0
Epitheloid Variant of Myoepithelioma of Parotid Gland: A Case Report
Abstract: Myoepithelioma is a benign neoplasm of salivary glands, which represents 1.5 % of all salivary gland neoplasm. This may arise from the minor or major salivary glands. Histopathologically this is a benign tumour...
Megaloblastic Anemia Secondary to Vitamin B12 and Folate Deficiency Presenting As Acute Febrile Illness and Pyrexia of Unknown Origin: A Prospective Study from Tertiary Care Hospital
Megaloblastic anemia is not uncommon in India, but data is insufficient regarding its presentation as pyrexia. There are many case reports on this topic but very few large sample size studies. We did a prospective study...
Management of Pemphigus Vulgaris by Dexamethasone cyclophosphamide pulse therapy: a SAIMS Experience
The standard treatment of pemphigus comprises of systemic steroids and other immunosuppressive agents. Dexamethasone−cyclophosphamide pulse (DCP) therapy has shown promising results in the management of these diseases. T...
Microbiological Profile and Their Antimicrobial Susceptibility in Infective Keratitis at Regional Eye Hospital, Visakhapatnam
Keratitis (corneal ulcer) is a leading cause of ocular morbidity and blindness worldwide especially in developing countries second only to cataract. It may be caused by bacteria, fungi, viruses and acanthamoeba. The aim...
Study of Systemic Illnesses in Malnourished Children
Malnutrition in children is widely prevalent in India. It is estimated that 57 million children are under weight (moderate and severe). More than 50% of deaths in 0-4 years are associated with malnutrition. The median ca...