Role of Th17 lymphocytes in pathogenesis of colorectal cancer
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
Colorectal cancer (CRC) is estimated to be the first leading cause of death from cancer among men and women in the EU. Every year in Poland, 15,254 cases of CRC are diagnosed, and 10,501 patients die of the disease, making it the second leading cause of death from cancer. In more than 90% of cases, the disease begins as adenomatous polyps with epithelial dysplasia as a common feature. Inflammatory bowel diseases (IBD), a group of chronic inflammatory diseases of the gastrointestinal tract characterized by remissions and relapses, constitute an independent risk factor of CRC development. CRC developing in IBD patients, however, has features distinct from sporadic cancer, suggesting the influence of unique factors. The high risk of CRC in IBD patients probably results from chronic inflammation. In most cases, neoplastic lesions arise within the inflamed gastrointestinal mucosa during the process of re-epithelization, which is a healing response to ulceration. The recently discovered Th17 lymphocytes, which demonstrate strong pro-inflammatory capabilities, might link the two diseases. Th17 lymphocytes produce a number of pro-inflammatory cytokines, such as interleukin (IL)-17A, IL-17F, IL-21, IL-22 and tumor necrosis factor (TNF)-a, and play a key role in mucosal defense against various pathogens. Numerous observations suggest that Th17 lymphocytes are involved in pathogenesis of different autoimmune diseases and pathologic inflammatory states. Mounting evidence suggests that Th17 cells contribute to the pathogenesis of IBD and CRC. However, their precise role in both diseases is unknown.
Authors and Affiliations
Jacek Karczewski, Małgorzata Mazur, Anna Rychlewska-Hańczewska, Zygmunt Adamski
Keywords
Related Articles
- EP ID EP67262
- DOI -
- Views 157
- Downloads 0
The dog as a model for comparative studies of lymphoma and leukemia in humans
Dogs have accompanied humankind for thousands of years. They share the same environment, and thus are exposed to the same environmental factors such as air pollution, tobacco smoke, and various chemicals. Recent developm...
Engineered spider silk: the intelligent biomaterial of the future. Part I
The unique properties of spider silk such as strength, extensibility, toughness, biocompatibility and biodegradability are the reasons for the recent development in silk biomaterial technology. For a long time scientif...
Botulinum toxin in medicine and cosmetology – two hundred years’ history and new perspectives
It has been nearly 200 years since the discovery of the botulinum toxin and the strain responsible for its synthesis Clostridium botulinum. Over this period, the knowledge about botulism and the use of botulinum toxin in...
Cytotoksyczny i proapoptotyczny wpływ bendamustyny zastosowanej pojedynczo lub w skojarzeniu z rytuksymabem na komórki przewlekłej białaczki limfocytowej in vitro
Rola kwasów żółciowych w patogenezie chorób jelit
Kwasy żółciowe nie tylko warunkują prawidłowe trawienie i wchłanianie lipidów oraz witamin rozpuszczalnych w tłuszczach, ale wywierają także istotny wpływ na funkcje motoryczne, sensoryczne i sekrecyjne jelit, przepuszcz...