The dog as a model for comparative studies of lymphoma and leukemia in humans

Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0

Abstract

Dogs have accompanied humankind for thousands of years. They share the same environment, and thus are exposed to the same environmental factors such as air pollution, tobacco smoke, and various chemicals. Recent development of veterinary care has led to a significant extension of dogs’ lifespan and allowed the diagnosis and treatment of a growing number of different diseases in this species. Among all diseases in dogs, cancer is considered the main cause of mortality, with lymphoproliferative disorders accounting for up to 30% of all canine cancers. Some of them, such as non-Hodgkin lymphoma (NHL) and lymphocytic leukemia, are very similar in the etiology, pathogenesis and response to treatment to the diseases occurring in humans. Due to anatomical and physiological similarities to humans, the dog is a useful model for the study of new therapeutic strategies for humans. Studies on the canine neoplasia are currently limited by the lack of well-characterized and widely available cell lines; thus, recently obtained canine NHL cell lines may become a valuable model for such studies. Investigation of their sensitivity to the antiproliferative effects of different factors should allow the creation of a database similar to the existing classification of human leukemias and lymphomas. This should enable quick and accurate diagnosis and selection of appropriate treatment based on phenotypic analysis and histopathological examination of clinical samples. The cooperation between human and veterinary oncologists gives the opportunity to use the dog as a model for the study of certain types of cancers presenting a challenge for modern medicine.

Authors and Affiliations

Aleksandra Pawlak, Bożena Obmińska-Mrukowicz, Andrzej Rapak

Keywords

Related Articles

Alcohol dehydrogenase – physiological and diagnostic Importance

Alcohol dehydrogenase (ADH) is a polymorphic enzyme, existing in multiple isoenzymes divided into several classes and localized in different organs. ADH plays a significant role in the metabolism of many biologically imp...

Renaturacja in vitro białek zakumulowanych w ciałach inkluzyjnych

Rekombinowane białka i enzymy dzięki ich heterologicznej ekspresji w prokariotycznych systemach ekspresyjnych są powszechnie wykorzystywane w diagnostyce, medycynie i przemyśle. Wysoki poziom ekspresji obcych białek w ko...

Wykorzystanie aptamerów oligonukleotydowych w terapii nowotworów

Aptamery są nową klasą cząsteczek, które odkryto w latach 90 ubiegłego wieku. Są to najczęściej oligonukleotydy DNA bądź RNA, których długość waha się między 20 a 80 nt. Wytwarzane są z wykorzystaniem metod SELEX, które...

Frequency of the use of biological treatment of patients with rheumatoid arthritis and ankylosing spondylitis in Lower Silesia

Background: Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are chronic connective tissue diseases. Inadequate treatment of RA and AS results in health failure, disability and premature death. In recent years,...

Wpływ czynników transkrypcyjnych na różnicowanie limfocytów T CD4[sup]+[/sup]

Wśród limfocytów T można wyodrębnić populacje komórek o wielorakich funkcjach i odmiennych szlakach różnicowania. Najbardziej zróżnicowaną grupę tworzą komórki mające na swojej powierzchni koreceptor CD4. Pod wpływem z...

Download PDF file
  • EP ID EP66942
  • DOI -
  • Views 130
  • Downloads 0

How To Cite

Aleksandra Pawlak, Bożena Obmińska-Mrukowicz, Andrzej Rapak (2013). The dog as a model for comparative studies of lymphoma and leukemia in humans . Advances in Hygiene and Experimental Medicine, 67(0), 471-480. https://europub.co.uk/articles/-A-66942