Sialic acids in squamous cell carcinoma of the head and neck
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2016, Vol 70, Issue
Abstract
Altered glycosylation is a universal characteristic of cancer cells, and various types of glycan structures are well‑known markers of tumor progression and invasion. The present article discusses this aspect of the role of sialic acid, biosynthesis of sialylglycoconjugates and the genetic basis of its disorder, as well as the effects and the correlation between altered sialylation and clinical prognosis in head and neck squamous cell carcinoma (HNSCC).Only a few studies concerning the level of sialic acid in head and neck tumors have been conducted so far. The conclusions of the published reports dedicated to that problem confirm the presence of elevated levels of total sialic acid in these tumors. The authors do not always agree with the level of free or associated form of sialic acid correlated with tumor size, severity of the condition, and lymph nodes. Comparing the progress that has been made in the diagnosis and treatment of other cancers thanks to extensive work on the role of sialic acids, we come to the conclusion that only further detailed studies of this subject in relation to HNSCC are able to answer the question whether the extent of glycoforms of sialic acid may act as a tumor marker or target of immunotherapy.
Authors and Affiliations
Izabela Bronikowska, Elżbieta Świętochowska, Mariusz Oleksiak, Eugeniusz Czecior
Keywords
Related Articles
- EP ID EP206089
- DOI -
- Views 118
- Downloads 0
Monoclonal antibodies in targeted therapy
Targeted therapy is a new therapeutic method consisting in the inhibition of specific molecular pathways. In modern therapy, the key role is played by monoclonal antibodies, included in the group of biological agents. Th...
The change of electric potentials in the oral cavity after application of extremely low frequency pulsed magnetic field
Electric potentials occurring in the oral cavity deserve attention as they may cause various diseases and subjective feelings, which are very difficult to treat. The aim of this study was to evaluate the electric potenti...
Effects of activation of endocannabinoid system on myocardial metabolism
Endocannabinoids exert their effect on the regulation of energy homeostasis via activation of specific receptors. They control food intake, secretion of insulin, lipids and glucose metabolism, lipid storage. Long chain f...
Eukaryotic TLS polymerases
TLS polymerases are able to replicate damaged DNA (called translesion DNA synthesis, TLS). Their presence prevents cell death as a result of violating the integrity of the genome. In vitro, they are mutator, but in vivo...
Czy suplementacja kwasem foliowym ma wpływ na stężenia czynników krzepnięcia i białka C-reaktywnego u osób z czynnikami ryzyka miażdżycy?
Wprowadzenie: Kwas foliowy (FA) może opóźniać tworzenie się zmian miażdżycowych. W chorobach układu krążenia obserwuje się podwyższone poziomy czynnika von Willebranda (VWF) w osoczu, co zwiększa ryzyko zakrzepicy. Fibry...