Role of Tranexamic Acid in patients with increased risk for Postpartum Hemorrhage Undergoing Cesarean Delivery in a Tertiary Care South Indian Teaching Hospital
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 1
Abstract
Background: Postpartum hemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality worldwide PPH responds to uterotonic drugs, including Oxytocin, Methyl Ergometrine, and Prostaglandins. Tranexamic acid is a synthetic lysine analog that exerts its effect by competitively blocking the lysine binding sites on plasminogen molecules, thus inhibiting the activation of plasminogen into plasmin, and acting as a fibrinolysis inhibitor. Consequently, clot breakdown is inhibited and excessive or recurrent bleeding is controlled. Objective: To assess the effects of tranexamic acid among patients undergoing cesarean delivery who were at high risk of postpartum hemorrhage. Methodology: A Randomized control trial was conducted in a tertiary care teaching hospital of South India. Women undergoing an elective or emergency cesarean delivery who were at high risk for postpartum hemorrhage were enrolled for the study. They were randomly assigned using sealed, opaque envelopes to receive 10 mg/kg tranexamic acid or normal saline 10 min before skin incision. The primary outcome was need for additional uterotonic drugs within 24 h after delivery. Results: 50 patients were assigned to each group.P value <0.05 was considered to be significant after obtaining a chi square value. Conclusion: As Postpartum hemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality worldwide more aggressive measures are needed for its prevention and control Intravenous tranexamic acid, administered before skin incision, significantly reduced the requirement for additional uterotonics among women at increased risk for postpartum hemorrhage.
Authors and Affiliations
Dr Nazima Allaudin
Keywords
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