ROLE OF VARIOUS OPIOID RECEPTORS IN OPIOID DEPENDENCE AND WITHDRAWAL SYNDROME
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 7
Abstract
Although dependence liability of opioids is widely recognized, the relative involvement of different opioid receptors mediating physical dependence is not completely known. The present study was aimed to explore the role of various types of receptors in opioid dependence and withdrawal. Mice were rendered dependent on opioids such as morphine, pentazocine, buprenorphine and ketamine which have differential agonistic activities on μ, κ, δ, and σ receptors. Withdrawal was precipitated by giving an opioid antagonist, naloxone. The magnitude of withdrawal was evaluated by scoring different withdrawal signs within the next 30 min following naloxone challenge. The results indicated the involvement of both μ and κ opioid receptor in the development of opioid dependence and withdrawal. The results also exclude the possibility of σ receptor involvement in the process. However, with the data obtained in the study, it is not possible to comment on the involvement of δ receptors in opioid withdrawal syndrome.
Authors and Affiliations
Vikas Seth
Keywords
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