Role of Vitamin D and IgE in bronchial asthma in children in Eastern India

Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5

Abstract

Background: Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation. The detrimental effects of vitamin D deficiency in pediatrics have become increasingly apparent and extend beyond skeletal health. Aims & Objectives: This study was carried out to evaluate the level of vitamin D and immunoglobulin E (IgE) in asthmatic patients of paediatric ages during exacerbation and after remission. Patients and Methods: This study was carried out on 56 bronchial asthma children of 4 to 14 years of age group attending the ‘Pediatric outpatient department’ of ICARE Institute of Medical Sciences, Haldia, with bronchial asthma diagnosed and classified according to Global Initiative for Asthma 2016 and 48 healthy age and sex matched individuals. Serum vitamin D and IgE were measured using enzyme-linked immunosorbent assay for all participants. Results: Serum IgE level was found significantly higher among bronchial asthma subjects with respect to controls (443.2 ± 237.3 versus 139.8 ± 82.06 IU/ml; P < 0.001). Moreover, serum 25 OH vitamin D levels were lower in bronchial asthma cases as compared to controls and were statistically significant (15.83 ± 7.44 versus 23.14 ± 8.29 ng/ml; P < 0.001). Serum vitamin D level showed an inverse correlation with IgE (r = - 0.77; P < 0.0001) level among bronchial asthma subjects, but no significant correlation was observed in controls (r = 0.077; P = 0.689). Conclusion: Despite these limitations it has been observed that serum vitamin D levels were lower and IgE levels were higher in patients suffering from bronchial asthma. A clear strong inverse correlation between vitamin D and Ig E also indicates a strong relationship in the pathogenesis of the disease.

Authors and Affiliations

Dr Sk. Rafikul Rahaman

Keywords

Related Articles

Association of Non-Alcoholic Fatty Liver Disease and Hepatic Enzyme Levels – A Case Control Study

Non alcoholic fatty liver disease (NAFLD) is considered as the hepatic representation of metabolic syndrome. It is one of the leading cause of asymptomatic elevation of serum transaminases in the western world. Our study...

Comparative Effect of Kinesiotape and Rigid Tape with Therapeutic Putty Exercise on Pinch Strenght in Instrumentalists – A Randomized Clinical Trial

Study objectives- The purpose of this study was to investigate the comparative effect of kinesio tape and rigid tape with therapeutic putty exercises on pinch strength in instrumentalists. Design- Comparative study Setti...

Low Cost Innovative Modification of Vacuum Assisted Wound Therapy

Management of acute and chronic wounds constitute a significant workload and financial burden for health care organizations and also has a negative impact over the quality of life of patients. Successful management of th...

An Estimation of Hospital Based Incidence of Neonatal Hyperbilirubinemia in Term Newborns and Associated Risk Factors in a North Indian Setting

Objective: To estimate the incidence of neonatal hyperbilirubinemia in newborns and associated risk factors. Study design: Prospective cross-sectional study. Study site: Department of Pediatrics, Integral Institute of Me...

A Clinical Study on Glycemic Profile of Non Diabetic Individual with Acute Ischemic Stroke and Its Short Term Prognostic Significance

The association between the diabetes mellitus and its macrovascular complications like stroke had studied in many aspects before. In addition to being the risk factor for the cause of the stroke, it affects the prognosis...

Download PDF file
  • EP ID EP285407
  • DOI -
  • Views 80
  • Downloads 0

How To Cite

Dr Sk. Rafikul Rahaman (2017). Role of Vitamin D and IgE in bronchial asthma in children in Eastern India. Journal of Medical Science And clinical Research, 5(5), 21991-21996. https://europub.co.uk/articles/-A-285407