Role of vitamin D in conversion of free T4 to T3: A hospital based cross sectional study
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 3
Abstract
Introduction and Objective:Few speculations are made regarding the conversion of T4 to T3 using vitamin D. Studies show that thyroid hormone inhibits 25 (OH) D l alpha hydroxylase and the latter also suppresses TSH secretion and exerts direct effects on thyroid cells such as inhibition of iodine uptake. Polymorphisms in the vitamin D receptor gene have been associated with autoimmune thyroid disease. There is a complex interplay between thyroid hormones and vitamin D which needs further clarification. Material and Method:A retrograde study of 50 cases was done in the biochemistry lab of Subharti Medical College whose vitamin D and thyroid profile was requested together. Thyroid profile was estimated by Vidas automatic analyzer and vitamin D was estimated using Robonik elisa reader using DRG kits. Results:There was a significant positive correlation of 25 OH-vitamin D with fT3 levels (r=0.22, p<0.5) as well as fT4 levels (r=0.41, p<0.05) and significant negative correlation with TSH (r= 0.15, p<0.5). Conclusion:There is definitely a direct relationship of vitamin D levels, with thyroid hormones which is confirmed by the indirect relation with TSH levels as per this preliminary study.
Authors and Affiliations
Ajay Kumar Das
Keywords
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