RP – HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ANALYSIS OF CLOBAZAM IN PHARMACEUTICAL DOSAGE FORMS
Journal Title: Journal of Atoms and Molecules - Year 2011, Vol 1, Issue 1
Abstract
A simple, precise and accurate RP-HPLC method was developed and validated for rapid assay of clobazamin tablet dosage form. Isocratic elution at a flow rate of 1ml min-1 was employed on a symmetry C18 column at ambient temperature. The mobile phase consisted of Methanol:water:OPA(0.1%) 35:40:25 (v/v/v). The UV detection wavelength was at 239nm.Linearity was observed in concentration range of 4-16ppm. The retention time for Clobazam was 4.71 min. The method was validated as per the ICH guidelines. The proposed method can be successfully applied for the estimation of Clobazam in pharmaceutical dosage forms.
Authors and Affiliations
K Gowri Baba Kumari, S Vanilatha, M Mary Theresa, N Prasanna, D Shantha Kumari, B Harika, P Sirisha
Keywords
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