RP-HPLC method development for the estimation of Levocetirizine and Phenylephrine hydrochloride in combined dosage form
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2013, Vol 1, Issue 2
Abstract
A rapid, accurate RP-HPLC method was developed for the simultaneous estimation of Levocetirizine and phenylephrine hydrochloride in combined dosage form. The HPLC separation was achieved on column Luna 5u C18 (20mm X 4mm) using mobile phase of methanol: Pot. Dihydrogen Phosphate Buffer (pH 6.0), (70:30) .The UV detection was performed at 251nm with flow rate of 1.0 mL/min. The retention time of Levocetirizine and Phenylephrine hydrochloride was found to be 8.42 min and 2.70 min with mean recovery 100.64 & 100.40% respectively. The proposed method was found useful in the routinely quantification of both drugs in combined dosage form.
Authors and Affiliations
Brij Bhushan, Uttam Singh Baghel, Ramandeep Singh, Yogesh Kumar
Keywords
Related Articles
- EP ID EP31456
- DOI -
- Views 427
- Downloads 2
Microemulsions: A potential novel drug delivery system
Microemulsions are defined as clear, transparent, thermodynamically stable, isotropic mixtures of oil and water, frequently in combination with a co-surfactant. Recently microemulsion formulations are widely used for t...
Evaluation of Anti microbial Activity of Extracts of Pedalium murex
As part of search for new biological active compounds from higher plants the crude organic extracts of Pedalium murexas screened. The purpose of this study was to investigate Indian plants potential antibiotic activity b...
Formulation of Gymnema Sylvestre mix Incorporated Foods for Diabetes Mellitus
Diabetes is defined as a group of metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secreti...
Neutral zone Concept for Severely Resorbed Ridges - A Clinical Report
Prosthetic rehabilitation of a patient with severely resorbed ridge is the most challenging therapy a prosthodontist can undertake. In order to have a favourable prognosis for the denture therapy, impression technique se...
Benign Tertian Malaria: “Really Benign”
There has been a recent trend to brand vivax malaria as a complicated one. A number of case reports are being published enumerating complications of vivax malaria. Although there is no doubt that complications can occu...