RP-HPLC method development for the estimation of Levocetirizine and Phenylephrine hydrochloride in combined dosage form
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2013, Vol 1, Issue 2
Abstract
A rapid, accurate RP-HPLC method was developed for the simultaneous estimation of Levocetirizine and phenylephrine hydrochloride in combined dosage form. The HPLC separation was achieved on column Luna 5u C18 (20mm X 4mm) using mobile phase of methanol: Pot. Dihydrogen Phosphate Buffer (pH 6.0), (70:30) .The UV detection was performed at 251nm with flow rate of 1.0 mL/min. The retention time of Levocetirizine and Phenylephrine hydrochloride was found to be 8.42 min and 2.70 min with mean recovery 100.64 & 100.40% respectively. The proposed method was found useful in the routinely quantification of both drugs in combined dosage form.
Authors and Affiliations
Brij Bhushan, Uttam Singh Baghel, Ramandeep Singh, Yogesh Kumar
Keywords
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