s Long Term Duration of Diabetes is a Factor to Cause Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus?
Journal Title: National Journal of Laboratory Medicine - Year 2017, Vol 6, Issue 4
Abstract
Introduction: Endothelial Dysfunction (ED) is an earliest pathological process of atherosclerosis. Endothelium regulates vascular tone, platelet activity, leukocyte adhesion and thrombosis. Impaired function of endothelium initiates the development of atherosclerosis. Nitric oxide is one of the most effective endogenous vasodilator and also a marker for ED. Aim: To assess whether long term duration of diabetes is a factor to cause ED and its complications in patients with Type 2 diabetes mellitus. Hence, the study has been designed to assess the ED in patients with long term duration of Type 2 diabetes for early prediction of vascular complications. Materials and Methods: The study was conducted on 47 Type 2 diabetic subjects. Among these 27 subjects with <5 years duration of diabetes (Group-I) and remaining 20 subjects with >5 years duration of diabetes (Group-II). Glucose, HbA1c, BMI and lipid profile were estimated by well established methods in auto-analyzer, MDA by Thiobarbituric Acid Reactive Substances (TBARS), total antioxidant capacity as Ferric Reducing Ability of Plasma (FRAP) and NO was estimated by kinetic cadmium reduction method using spectrophotometer. Statistical analysis was performed by “Kruskal-Wallis” test. Result: Significantly low level of NO was identified in Type 2 diabetic patients with >5 years duration of disease compared to <5 years duration. MDA shows significantly high in >5 years duration of diabetes and no significant difference in the level of FRAP among the study groups. It has also shown significantly high level of age in >5 years duration of Type 2 diabetes than <5 years. But, no significant differences in the levels of HbA1c, lipid profile were identified between two study groups. Conclusion: Age and oxidative stress (lipid peroxidation) has been recognized as risk factors for ED and future complications in patients with more than 5 years duration of Type 2 diabetes.
Authors and Affiliations
Siva Prasad Palem, Philips Abraham, Sachu Philip
Keywords
Related Articles
- EP ID EP376719
- DOI 10.7860/NJLM/2017/29048:2251
- Views 150
- Downloads 0
Evaluation of Phenotypic Methods for Detection of Biofilm Formation in Uropathogens
Introduction: Urinary tract infection (UTI) is one of the leading causes of morbidity encountered in clinical practice. Biofilm produced by the urinary pathogens leads to recurrent and recalcitrant UTI there by contribut...
Average Values of Neutrophil Lymphocyte Ratio among a Representative Sample of Adult Population in a Tertiary Care Teaching Hospital
Introduction: Several studies have been conducted over the years for a simple, reliable, cost effective investigation to know the intensity of systemic inflammation in patients suffering from shock, major surgery, sepsis...
Anaemia in Pregnant Women in Labour and its Correlation with Newborn Birth Weight-How Far we have Reached?
Introduction: Maternal anaemia is one of the important preventable causes of low birth weight in newborn leading to maternal and fetal morbidity and mortality. Maternal complications and poor perinatal outcome are highly...
A Clinico-histopathological Study of Appendageal Skin Tumours Over A Period of Four Years in A Tertiary Care Center
Introduction: Appendageal tumours arise from pilo sebaceous apparatus, eccrine and apocrine sweat glands. A great majority of these tumours are benign in nature. A clinicohistopathological co-relation is essential for a...
High Density Lipoprotein Cholesterol as a Risk Factor of Coronary Artery Diseases in Young Western Indians: A Comparison with Other Lipid Markers
Introduction: Dyslipidemia – a modifiable risk factor of coronary artery diseases (CAD) is often subjected to ethnic variations. Different communities are known to possess different pattern of lipid abnormalities and stu...