S100B Protein in Serum as a Prognostic Marker for Brain Injury in Term Newborn Infants with Hypoxic Ischemic Encephalopathy - New Strategy for Early Brain Damage
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2012, Vol 5, Issue 4
Abstract
Background: The aim was to investigate whether S100 in serum is a prognostic marker of cerebral injury in term newborn infants with hypoxic ischemic encephalopathy (HIE) after perinatal asphyxia. Material and Methods: All risk neonates with severe asphyxia, admitted to the neonatal and Pediatric Intensive Care Unit at the University Pediatric Hospital in Skopje-Macedonia within 24h of injury were eligible for inclusion in the study. One serum blood sample was obtained from each patient at the 24h post-injury time-point, than day 3 and day 7. S100B levels were measured using ECLIA method (ElectroChemil-Luminiscence Immuno Assay-Elecsys 2010-Roche Diagnostic). Results: One hundred and nineteen neonates were recruited. The avarage serum S100B levels for the control group (N=48) was 0.12 microgL(-1) (cut-off point). S100B levels were significantly higher in asphyxiated term neonates N=29; M= 0.64. Infants with moderate and severe HIE had significantly higher S100 levels on postnatal day 1 (p = 0.031) and day 2 (p = 0.008) than infants with mild or no HIE. Increased S100 levels were significantly inversely correlated with perinatal pH in the infants and associated with abnormal CTG at admission to the labor ward. Conclusion: Early determination of serum S100 may reflect the extent of brain damage in infants with HIE after asphyxia.
Authors and Affiliations
Aspazija Sofijanova| University Children’s Hospital, Medical Faculty, Ss Cyril and Methodius University of Skopje, Republic of Macedonia, Katica Piperkova| University Children’s Hospital, Medical Faculty, Ss Cyril and Methodius University of Skopje, Republic of Macedonia, Olivera Jordanova| University Children’s Hospital, Medical Faculty, Ss Cyril and Methodius University of Skopje, Republic of Macedonia
Keywords
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- EP ID EP8890
- DOI 10.3889/MJMS.1857-5773.2012.0263
- Views 332
- Downloads 15
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