Evaluation of Hepatoprotective Activity of Aqeous Leaf Extract of Swietenia Mahogani (Maliaceae) in Chronic Alcohol-Induced Liver Injury in Rats
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2011, Vol 4, Issue 1
Abstract
Aim. This study investigated the hepatoprotective effects of aqueous leaf extract of Swietenia mahogani (Maliaceae) in chronic alcohol-induced liver injury in rats. Material and Methods. The animals were given increasing concentrations (10% ethanol (v/v) in water for 1week, 20% (v/v) for another 2 weeks and 30% (v/v) for 9 weeks) per os daily. Treatment with the extract (250 and 500 mg/kg) was instituted 6 h after given the alcohol for the same period the alcohol intake lasted. Thereafter, the activities of alanine aminotransferase (ALT), aspartate amino transferase (AST) and alkaline phosphatase (AP) were assayed in the serum. The levels of other biochemical markers of organ damage such as total bilirubin and creatinine, as well as pentobarbitone sleeping time were determined. Histological examination of the liver was also performed. Results. The extract at all doses significantly (P<0.05) reduced the serum activities of ALT, AST, AP, serum levels of bilirubin and creatinine in comparison with the negative control that received only alcohol. The duration of pentobarbital induced hypnosis was also significantly shortened. The histopathological result showed significant (P<0.05) protection in the extract treated groups when compared with the group that received alcohol alone. Conclusion. The extract displayed significant (P<0.05) hepatoprotective activity in the model used in this study.
Authors and Affiliations
Samuel Udem| University of Nigeria, Veterinary Physiology/Pharmacology, Enugu State, Nsukka 234, Nigeria, Innocent Nwaogu| University of Nigeria, Veterinary Anatomy, Enugu State, Nsukka 234, Nigeria, Obinna Onyejekwe| University of Nigeria, Veterinary Physiology/Pharmacology, Enugu State, Nsukka 234, Nigeria
Keywords
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- EP ID EP8782
- DOI 10.3889/MJMS.1857-5773.2011.0154
- Views 312
- Downloads 16
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