Safety and efficacy of vildagliptin-metformin to glimepiride-metformin in type 2 diabetes mellitus patients - A comparative study
Journal Title: Medpulse International Journal of Pharmacology - Year 2019, Vol 10, Issue 2
Abstract
Background:Metformin and Vildagliptin have independent glucose-lowering properties and may increase GLP-1 levels by working through complementary mechanisms. The combination of metformin and glimepiride is a well-established therapy for type 2 DM.Aim: To compare the efficacy and safety of vildagliptin-metformin and glimepiride-metformin treatment in type 2 diabetic patients.Material and Methods:Patients was randomly assigned in (1:1) ratio after randomization to either of two groups (35 in each group), one group prescribed glimepiride(1mg) +metformin (500mg) twice daily half an hour before meals and other group vildagliptin(50mg)+ metformin(500mg) twice daily half an hour before meals. HbA1c, FBS, PPBS was repeated at the end of 3rd month.Results:The mean HbA1c levels at baseline (0 weeks) were 8.80 ±0.62and 8.99 ±0.37 in Group A and Group B respectively. Similarly, at 12 weeks mean HbA1c levels were 6.47±0.44 and 6.42±0.42 in Group A and Group B respectively. The change in percentage of HbA1c at 12 weeks was -26.06% and -27.86% in Group A and Group B respectively but no statistical significance different was found. (P=0.26). The HbA1c levels < 7 were achieved among 29 (41.43%) subjects in Group A as compared to 28 (40%) subjects in Group B.The difference between HbA1c levels among study groups was not statistically significant. (P=0.75).Conclusion:The efficacy and tolerability of vildagliptin, was similar, with no significant differences, when used to treat type 2 diabetic patients with inadequate blood glucose control by dual combination of metformin and glimepiride.
Authors and Affiliations
P KalaiSelvi, D Nishanthini
Keywords
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- EP ID EP615747
- DOI 10.26611/10101022
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