Comparison of effects of metformin with combination of glimepride and metformin in type 2 diabetes patients
Journal Title: Medpulse International Journal of Pharmacology - Year 2018, Vol 6, Issue 3
Abstract
Background: The use of a fixed-dose combination pill of sulfonylurea and metformin has recently increased. Using a fixed-dose combination pill can improve patient compliance. Aim: To compare the effects of tformin with combination of glimepiride and metformin in type 2 diabetes patients. Material and Methods: A total of 120 patients with Type 2 DM with simple random sampling were included in the study. Study subjects selected as Group I (N=30): Diagnosed cases of T2DM being treated with Metformin alone and Group II (N=30): Diagnosed cases of T2DM being treated with a combination of Glimepiride and Metformin. Fasting and post prandial blood glucose estimation, HbA1c, MDA estimation and Serum lipid profile timation was done at duration of 0, 6, 12 and 18 months. Results: There was significant reduction in fasting blood glucose level, postprandial blood glucose and glycosylated haemoglobin by 51.57%, 50.16% and 32.15% respectively, from the baseline after 18 months of treatment with a combination of Metformin and Glimepiride as compared to monotherapy with Metformin alone. Total cholesterol, serum triglyceride and LDL cholesterol also reduced significantly in combination therapy. Conclusion: Combination treatment with Metformin plus Glimepiride was more effective in improving hyperglycemia, oxidative stress and lipid status in type 2 diabetics.
Authors and Affiliations
Keerti Patil, Sachin Bhavdhankar
Keywords
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