Salivary Interleukin-6 Levels in Patients with Periodontitis Stage IV
Journal Title: Meandros Medical and Dental Journal - Year 2021, Vol 22, Issue 2
Abstract
Objective: The role of interleukin-6 (IL-6) in the pathogenesis of periodontal disease and tissue destruction at the periodontal site has been widely reported. This study aimed to evaluate the salivary IL-6 levels in patients with stage IV periodontitis. Materials and Methods: The study included 28 patients who were diagnosed with periodontitis stage IV and the control group of 22 periodontally healthy patients. All the patients were systemically healthy. Saliva samples were collected, and clinical periodontal measurements, including probing depth (PD), clinical attachment level (CAL), papilla bleeding index (PBI), the percentage of sites with bleeding on probing (BOP) %, plaque index (PI) and calculus index (CI), were recorded. The unstimulated saliva of each patient was collected by a saliva collector, and all samples were analysed using the enzyme-linked immunosorbent assay method for the detection of IL-6. Results: The mean value of salivary IL-6 in patients with periodontitis stage IV was 22.18±5.96 pg/mL. In the control group, the average measured value of IL-6 was 2.23±2.17 pg/mL. The periodontitis group had a significantly higher salivary IL-6 levels than the control group. A strong positive correlation was observed between the salivary IL-6 and clinical periodontal parameters (PD, CAL, PBI, BOP %, PI and CI) in patients with periodontitis stage IV (p<0.0001). Conclusion: We demonstrated a statistically significant relationship between periodontal parameters and salivary IL-6 in patients with periodontitis stage IV. New studies are needed to accurately establish salivary IL-6 potential as a biomarker for periodontal disease monitoring, including all stages and grades of periodontitis.
Authors and Affiliations
Zerina Hadzic, Enes Pasic, Mirsada Hukic, Mirjana Gojkov Vukelic, Sanja Hadzic
Keywords
Related Articles
- EP ID EP694412
- DOI 10.4274/meandros.galenos.2021.05945
- Views 82
- Downloads 0
2015 World Health Organization Classification of Pulmonary Tumors “A Valid Classification Until the New Classification”
In 2011, a research panel funded by the International Association for the Study of Lung Cancer (IASLC), American Thoracic Society and European Respiratory Society proposed a variety of significant improvements to all lun...
Does Medication-related Osteonecrosis of the Jaw Affect Maxillary Sinus Volume and Mucosal Thickness?
Objective: Bisphosphonates (BPs) are commonly prescribed drugs because of their antiresorptive effects. However, BPs may cause medication-related osteonecrosis of the jaw (MRONJ). This study aimed to compare the maxillar...
Comparison of Two Morphometric Linear Methods to Measure the Alveolar Bone Loss Induced by Experimental Periodontal Disease in Rats
Objective: The aim of this study was to compare the direct and indirect linear morphometric measurements for the evaluation of alveolar bone loss after experimentally induced periodontitis in rats. Materials and Methods...
Before Minimally Invasive Parathyroidectomy in Patients with Primary Hyperparathyroidism Ultrasonography Accompanied by Methylene Blue Staining: A Case Guided Review
Primary hyperparathyroidism is an endocrine disease that leads to the excessive secretion of the parathyroid hormone. In most patients with an underlying disease of parathyroid adenoma, its excision usually provides the...
Endoscopic Dacryosistorhinostomy with or without Stent
Objective: The purpose of this study is to investigate the effect of the use of silicone stent in endoscopic dacryocystorhinostomy operation on the surgical success and to compare the results of the patients who had sili...