SAMBUCUS NIGRA LINN: IN VIVO STUDIES ON RABBITS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 7
Abstract
Objective: The research work was carried out to explore the safety and efficacy of a low dose of Sambucus nigra Linn [S. nigra] extract on hematological, biochemical and histopathological parameters of rabbits organs (kidney, liver, stomach and heart). Methods: Sambucus nigra extract was given orally for 90 d to test group rabbits [Test female (SF); Test male (SM)]. Then blood samples of control [C (female); C (male)] and test rabbits were collected by cardiac puncture and changes in hematological, biochemical and histopathological parameters were observed and interpreted. Results: Gender-based differences were observed in hematological, kidney function, liver function, cardiac enzymes and lipid profile investigations. Urine analysis showed similar results as that of standard and control drug. No noteworthy pathology was observed in heart, stomach, liver and kidney tissues of rabbits, treated with Sambucus nigra in a dose of 25 mg/kg/day. Conclusion: Our results justify the well-documented safe and effective use of Sambucus nigra in medicine for curing various pathologies.Keywords: Black Elder, Anthocyanins, Anti-oxidant, Anti-viral, Europe
Authors and Affiliations
Farah Saeed, Mansoor Ahmad
Keywords
Related Articles
- EP ID EP576266
- DOI -
- Views 53
- Downloads 0
POTENTIAL EFFECTS OF DUKU (LANSIUM DOMESTICUM CORR) AND LANGSAT (LANSIUM DOMESTICUM JACK) EXTRACTS ON THE GROWTH OF BIFIDOBACTERIA SPP.
Objective: Lansium domesticum Corr. is a fruit tree species belongs to the family Meliaceae. There are numerous forms of the species and grouped into two main types: Duku and Langsat. The objective of this study is to sc...
SYNTHESIS OF QUINOLINYL-OXADIAZOLE AS A POTENT ANTIBACTERIAL AGENT AND SA-FABI INHIBITOR
Objective: Microbial resistance to currently marketed drugs is a serious problem worldwide and there is a vital need to develop novel antibiotics. Enoyl-ACP reductase (FabI) is essential for fatty acid biosynthesis and h...
LOADING OF CLARITHROMYCIN AND PACLITAXEL ON SYNTHESIZED CdS/NiO NANOPARTICLES AS PROMISING NANOCARRIERS
Objective: In this study cadmium sulfide (CdS) and nickel oxide (NiO) nanoparticles were synthesized and applied as novel nanocarriers for antibacterial drug clarithromycin (CLA) and anticancer drug paclitaxel (PTX) to i...
STRUCTURE BASED DRUG DESIGNING, SCORING, AND SYNTHESIS OF SOME SUBSTITUTED SULPHONYLUREAS/GUANIDINE -BASED DERIVATIVES AS HYPOGLYCEMIC AGENTS
Objective: The present work deals with the designing, scoring, synthesis and, characterization of 1-(4-(2-(4-Substitutedphenylamino)-2-oxoethyl)phenylsulfonyl)-3-(4-substitutedbenzoyl)urea (5A-5B),1-(4-(2-(4-substitutedp...
PURIFICATION AND BIOCHEMICAL CHARACTERIZATION OF A T/TN SPECIFIC LECTIN FROM LEPECHINIA BULLATA SEEDS (LAMIACEAE)
Objective: This study focused on purifying and characterizing a lectin from Lepechinia bullata (L. bullata) seeds, and determining its specificity towards tumour-associated carbohydrate-antigens.Methods: Pigments were re...