SAMBUCUS NIGRA LINN: IN VIVO STUDIES ON RABBITS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 7
Abstract
Objective: The research work was carried out to explore the safety and efficacy of a low dose of Sambucus nigra Linn [S. nigra] extract on hematological, biochemical and histopathological parameters of rabbits organs (kidney, liver, stomach and heart). Methods: Sambucus nigra extract was given orally for 90 d to test group rabbits [Test female (SF); Test male (SM)]. Then blood samples of control [C (female); C (male)] and test rabbits were collected by cardiac puncture and changes in hematological, biochemical and histopathological parameters were observed and interpreted. Results: Gender-based differences were observed in hematological, kidney function, liver function, cardiac enzymes and lipid profile investigations. Urine analysis showed similar results as that of standard and control drug. No noteworthy pathology was observed in heart, stomach, liver and kidney tissues of rabbits, treated with Sambucus nigra in a dose of 25 mg/kg/day. Conclusion: Our results justify the well-documented safe and effective use of Sambucus nigra in medicine for curing various pathologies.Keywords: Black Elder, Anthocyanins, Anti-oxidant, Anti-viral, Europe
Authors and Affiliations
Farah Saeed, Mansoor Ahmad
Keywords
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