Sarilumab:A New Arsenal for Rheumatoid Arthritis
Journal Title: International Journal of Medical and Dental Sciences - Year 2017, Vol 6, Issue 2
Abstract
Rheumatoid arthritis is a debilitating disease that has significant impact on quality of life. Biological and non biological DMARDs improved the outcome in RA patients. New agents are still required in inadequate responders or intolerant patients. FDA has recently approved a new drug Sarilumab, a monoclonal antibody for the treatment of moderate to severe form of RA which acts by binding to Interleukin receptor 6 and interrupts the resultant cytokine-mediated inflammatory signaling.
A Study of Prevalence of Aerobic Bacteria and Fungi in Sputum Specimens of Patients with Post Tubercular Bronchiectasis
Background: Patients with Post TB bronchiectasis colonize many aerobic bacteria and fungi and lead to an increase in exacerbations and decrease in quality of life. Objective: To study the prevalence of aerobic bacteria...
Mephentermine Dependence: Emerging Trend of Substance Abuse and its Challenges
Dependence on Mephentermine, a widely used sympathomimetic pressor agent, is so far not extensively reported. In current report, we describe a male patient consuming extraordinary high amount of Mephentermine who develop...
Mesocephaly to Brachycephaly Shift as Seen in Punjabi Children
As oral cavity is an integral part of general health, persistent and unrelenting stress often becomes a danger affecting the oral health and overall health causing various psychosomatic disorder...
Validation of Two Rapid Serological Tests for Human Brucellosis Detection
As brucellosis have several non-specific clinical phases, the search for reliable diagnosis of the disease is necessary. Therefore, for serological determination of brucellosis, rapid immunofiltration tests designated as...
Unusual Supero-Lateral Dislocation of Intact Bilateral Mandibular Condyles Associated with Right Parasymphysis Mandibular Fracture:A Case Report and Review of Literature
The dislocation of the mandibular condyle / condyles occurs most commonly in an anterior direction due to trauma. This is a known fact as due to pull of lateral pterygoid muscle. On the contrary, posterior, superior, or...