Schizophrenia Management: An Update
Journal Title: Nepal Journal of Neuroscience - Year 2006, Vol 3, Issue 1
Abstract
Schizophrenia is the most disabling psychiatric disorder and one of the world’s top ten causes of long- term disability, affecting 1% of the population worldwide. Traditional or typical antipsychotics appear to act principally on dopamine(D2) receptors and they relieve mainly the positive symptoms in approximately 75% of the patients and produce much less improvement in negative symptoms. Unfortunately, all of them produce extrapyramidal side effects(EPS) to a varying degree. Newer antipsychotics (second generation or atypical ) appear to have additional blocking action on serotonin receptors, are more likely to relieve negative symptoms and are relatively free from EPS seen with typical/first generation neuroleptics.In this review, the efficacy of the novel atypical antipsychotics on the resistant schizophrenia is discussed with an emphasis on the future medication which are claimed to be more effective in the management of schizophrenia. These medicines are still in the various stages of clinical testing and development.
Authors and Affiliations
Parul Lakhanpal, MD
Keywords
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