Scientific Validation of Antiurolithiatic Activity of Luffa acutangula Root Extract against Ethylene Glycol Induced Urolithiasis in Wistar Albino Rats
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 12
Abstract
Abstract: Nephrolithiasis or renal stone disease remains a significant health problem in the adult population, with serious medical consequences, throughout a patient’s lifetime. The worldwide incidence of urolithiasis is quite high.The present-day medical management of nephrolithiasis is either costly or not without side-effects.In contrast, traditional medicines have offered a substitute for many diseases due to its least side effects. The present study was undertaken with an aim of evaluating the antiurolithiasis effect of ethanolic root extract of Luffa acutangula against, ethylene glycol induced urolithaisis in rats. The animals were divided in to 5 groups of 6 animals each. Group I served as normal control and received regular diet and drinking water ad libitum. Ethylene glycol (0.75%) in drinking water was fed to Groups II-V for induction of renal calculi till 28th day. Group II served as urolithiatic control, received drinking water and group III received standard antiurolithiatic drug, Cystone (750mg/kg weight) from 15th day till 28th day. Groups IV and V served as curative regimen received ethanolic root extract of Luffa acutangula (200 and 400 mg/kg, respectively) from 15th day till 28th day once daily by oral route. On 28th day, urine samples were collected from all the groups and analysed Calcium, Phosphate and Oxalate content. Blood was also withdrawn through retro-orbital puncture under anesthesia; serum was separated and subjected to Creatinine, Uric acid and Urea Nitrogen. Treatment with cystone and Luffa acutangula reversed the elevated levels of Calcium, Phosphate and Oxalate in urine and Creatinine, Uric acid and Urea Nitrogen in blood induced by ethylene glycol. From the result it was concluded that the ethanolic root extract of Luffa acutangula exhibited antiurolithiatic activity against ethylene glycol induced urolithiasis in wistar albino rats. Keywords:Luffa acutangula, Urolithiasis, Cystone and Kidney Stone.
Authors and Affiliations
Prathap B
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