Scleroderma or Systemic Sclerosis - Treatment by DexamethasoneCyclophosphamide Combination Pulse Therapy
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 3
Abstract
Introduction: Systemic sclerosis is a multisystem, autoimmune disease of connective tissues involving skin, gut, lungs, kidneys and vessels. Present treatment is largely based on targeting specific components of pathogenesis like immune activation, fibrosis of skin and obliterative vasculopathy. In present study immunosupressive, anti-inflammatory effect of corticosteroids and cyto toxic effects of cyclophosphamide on lymphocytes has been used to this effect. Study aimed to determine the efficacy and weigh the risk and benefit ratio of DexamethasoneCyclophosphamide combination pulse therapy in patients of systemic sclerosis. Material and methods: 15 patients of Systemic sclerosis fulfilling the inclusion criteria were given DC pulse therapy every 28 days. The assessment of these patients was done under the following headings for 6 months:- Skin biopsy, modified Rodnan score, pulmonary function test, Raynaud’s phenomenon, ESRvalue, subjective improvement, quality of life index scoring and any side effects of pulse therapy. Result: There was a good reduction in Rodnan score, 8 patients showed excellent improvement in pulmonary function test. Subjective improvement was noticed in all patients with quality of life index improved in all patients. No major side effects were noticed during the study and follow up. Conclusion: DC pulse therapy is an excellent option for patients of Systemic sclerosis in the early stages of the disease, before complete fibrosis of lungs occur.
Authors and Affiliations
Sakshi A, Praveen Kumar Rathore, Kaushal Kumar Singh
Keywords
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