Scoring of Micronuclei in Fine Needle Aspiration Cytology of Breast Carcinoma
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 1
Abstract
Background: Micronuclei (MN) scoring has been used as a biomarker of chromosomal damage, genome instability and cancer risk. Micronuclei scoring can be exploited in the screening of high risk population of a specific cancer. Aims: 1. to score the micronuclei in the fibroadenomas and infiltrating ductal carcinoma (IDC). 2. To compare the micronuclei scores in fibroadenomas and various grades of infiltrating ductal carcinomas. Methodology: A retrospective study was done in the Department of Pathology including thirty cases of fibroadenoma and thirty cases of infiltrating ductal carcinoma. Micronuclei scoring was done on Papanicolaou and Hematoxylin and Eosin stained smears of these cases. Carcinoma were graded by Robinson cytological grading. Statistical analysis was done to assess the difference in MN scoring between the Fibroadenoma group and IDC. Results: Mean micronuclei score range was 1.9±1.7 in Fibroadenoma and 25.1±11.7 in Infiltrating duct carcinoma. It was 20.2±10.3, 23.1±9.5 and 29.9±12.4 in IDC cytological grades 1,2
Authors and Affiliations
Susmitha M. S.
Keywords
Related Articles
- EP ID EP512509
- DOI 10.21088/ijprp.2278.148X.7118.17
- Views 56
- Downloads 0
Immunohistochemical Correlation with Morphological Evolution of Urinary Bladder Tumors
Context: Urinary bladder diagnosis can be challenging and conventional markers used were cytokeratins. The new additions are GATA 3, uroplakin and S100P. This study helps to analyze immunohistochemical expression of pane...
Radiological and Histopathological Spectrum of CNS Tumors in Tertiary Care Centre: A Retrospective and Prospective Study
Background: To study the spectrum of CNS tumors in different age groups, locations, clinical presentations, their radiological and histo-pathological profile in local population of Kanpur. Methods: This study includes 11...
Hematological Indices in Thyroid Disorders
Context: Thyroid hormones are the important hormone helping in body metabolism. Every cell in the body depends on thyroid hormones for regulation of their metabolism. They are also known to play an important role in hema...
A Study of Correlation of Pap Smear with Histopathological Findings in Lesions of Cervix
Introduction: Cervical cancer is the most common, preventable cancer and does not develop suddenly from normal epithelium but is presented by a spectrum of intraepithelial neoplasia. Pap smear is an ideal screening and l...
Adenomyoepithelioma of Breast in an Adolescent Girl: A Rare Clinical Presentation
The growing awareness of female breast cancer has led to increased sensitivity toward pAathological breast conditions in pediatric patients. Palpable breast masses arising in adolescent and pubertal girls are uncommon. T...