Reproducibility of Modified Gleason Scoring System and Grade Group in Prostate Carcinoma on Microphotographs
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2017, Vol 6, Issue 4
Abstract
Background: Pathologists can quickly transmit the microscopic images photographed in a certain location to remote centers for analyzing the images. Gleason scoring system forms an important prognostic parameter for therapeutic decision and in the overall management of prostate cancer patients. Aims: 1. To study various histopathological patterns of prostatic carcinoma. 2. To evaluate the reproducibility of modified Gleason scoring system and Grade group in prostate carcinoma on microphotographs. Material and Methods: A retrospective study of invasive prostate cancer cases was conducted from January 2014 to October 2016. It was an analytical type of study at a rural tertiary care institute. Histopathology slides of prostate adenocarcinoma slides were retrieved, reviewed, scored and graded according to World Health Organization [WHO] 2016. The representative images captured by 13 megapixel mobile camera were sent to two pathologists by Email and were evaluated separately. The primary Gleason pattern, secondary Gleason pattern, total Gleason score and Grade groups were documented. Concordance and kappa statistics was applied. Results: Twelve cases were analyzed. Concordance was better in secondary Gleason pattern when compared with primary Gleason pattern, total Gleason score and Grade group. The present study showed substantial agreement in primary Gleason pattern; and substantial to almost perfect agreement in secondary Gleason pattern, Gleason total score and grade group. The overall performance of both the pathologists was satisfactory. Conclusions: Modified Gleason scoring system and grade group has good reproducibility in prostate carcinoma on microphotographs. The analysis of representative images is a feasible and time saving exercise.
Authors and Affiliations
Anupama M.
Keywords
Related Articles
- EP ID EP471601
- DOI 10.21088/ijprp.2278.148X.6417.39
- Views 78
- Downloads 0
Evaluation of Fluorescent Staining for the Diagnosis of Leprosy in Tissue Sections and its Histopathological Correlation : Comparision with ZN Staining
Introduction: to study histopathological evaluation and its correlation with fluorescent staining used in the diagnosis of leprosy in tissue section and comparision of fluorescent staining with zn staining. Materials and...
Histopathological Spectrum of Appendiceal Lesions with Associated Unusual Findings in Appendicetomy Specimens
Background: Acute appendicitis is the one of the most common surgical emergencies in world wide. Gold standards method for diagnosis of acute appendicitis is histopathological examination of appendectomy specimen. Append...
Accuracy of Intraoperative Frozen Section inthe Diagnosis of Ovarian Neoplasms in a Tertiary Care Centre
Background: Frozen section is an important tool in the intraoperative diagnosis of ovarian tumours which guides the surgeon in tailoring the surgical therapy, especially in younger women. Aim: To determine the accuracy o...
Clinicocytomorphological Spectrum of Lymph Node Lesions by Fine Needle Aspiration: A Retrospective Study
Background: The commonest clinical presentation in any out patient department is lymphadenopathy. Fine needle aspiration cytology (FNAC) is a simple, reliable, rapid and inexpensive method to diagnose various cause lymph...
Role of HER-2/Neu Expression in Premalignant and Malignant Lesions of Uterine Cervix
Background: HER-2/neu is a gene localized on chromosome 17q21 which encodes a growth factor receptor like molecule with tyrosine kinase activity and is known to encode a transmembrane glycoprotein. Aim: To study the expr...