Role of HER-2/Neu Expression in Premalignant and Malignant Lesions of Uterine Cervix
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 11
Abstract
Background: HER-2/neu is a gene localized on chromosome 17q21 which encodes a growth factor receptor like molecule with tyrosine kinase activity and is known to encode a transmembrane glycoprotein. Aim: To study the expression of HER2/neu in benign and malignant lesions of cervix. Material and Methods: The present study was conducted on 100 cases of resected cervical tissue specimen suspected to have neoplastic lesions and hysterectomy specimen already diagnosed as carcinoma on cytology for a period of 12 months (September 2018 to August 2019). Results: Majority of benign cases were negative for HER-2/neu except few cases and positivity was higher in malignant than premalignant. Positivity was also higher in adenocarcinoma as compared to squamous cell carcinoma. Conclusion: HER-2/neu serves as a biological marker to identify high risk subgroups and can be useful as target for new treatment modalities.
Authors and Affiliations
Shaila Kumari Mitra
Histopathology of Endometrium in Patients Presenting with Abnormal Uterine Bleeding
Background: Abnormal uterine bleeding (AUB) is the most commonand challenging problems presenting to gynaecologists now-a-days. Any bleeding pattern deviated from normal menstrual cycle results in AUB. Aims and objectiv...
Study of Ultrasound Guided Fine Needle Aspiration Cytology of Abdominal and Pelvic Masses
Background and Aims: Fine Needle Aspiration (FNA) which is used for making a cytological diagnosis has become an indispensable component of the work-up of many abnormalities. Intra-abdominal masses always remain an enigm...
Histomorphology and Immunohistochemistry in Endometrial Carcinomas
Context: Endometrial carcinoma is one of the most common malignancies occurring in postmenopausal females. Endometrial carcinomas are of two types, type I and type II. Type I is the most common encountered type of endome...
Survivin: A Prognostic Biomarker in Oral Squamous Cell Carcinoma (OSCC)
Not available
Fine Needle Aspiration Cytology (FNAC): An Easy and Effective Tool for the Evaluation of Cervical Lymph Node Masses
Background: Given that the clinical and radiological examinations of lateral cervical masses are not always sufficient for deciding on appropriate management, the cytological examination of the material obtained by fine-...