Role of HER-2/Neu Expression in Premalignant and Malignant Lesions of Uterine Cervix
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2018, Vol 7, Issue 11
Abstract
Background: HER-2/neu is a gene localized on chromosome 17q21 which encodes a growth factor receptor like molecule with tyrosine kinase activity and is known to encode a transmembrane glycoprotein. Aim: To study the expression of HER2/neu in benign and malignant lesions of cervix. Material and Methods: The present study was conducted on 100 cases of resected cervical tissue specimen suspected to have neoplastic lesions and hysterectomy specimen already diagnosed as carcinoma on cytology for a period of 12 months (September 2018 to August 2019). Results: Majority of benign cases were negative for HER-2/neu except few cases and positivity was higher in malignant than premalignant. Positivity was also higher in adenocarcinoma as compared to squamous cell carcinoma. Conclusion: HER-2/neu serves as a biological marker to identify high risk subgroups and can be useful as target for new treatment modalities.
Authors and Affiliations
Shaila Kumari Mitra
Keywords
Related Articles
- EP ID EP530119
- DOI 10.21088/ijprp.2278.148X.71118.11
- Views 64
- Downloads 0
A Study on Fine Needle Aspiration Cytology of Cervical Lymph Nodes
Introduction: Aim of the Study: To study the spectrum of lesions in cervical lymph nodes onFine Needle Aspiration Cytology. Materials and Methods: This was a prospective study done over a period of two and half yearsin t...
Premalignant Lesions and Incidental Carcinoma in Clinically Diagnosed Benign Prostatic Hyperplasia (BPH)
Background: Histological examination of the prostate must also include the description of some important aspects which are present associated with Benign Prostatic Hyperplasia (BPH) and which may condition the progressio...
Cytomorphological Patterns of Tuberculous Lymphadenitis in Correlation with AFB Positivity
Objective: Despite progress in prophylaxis and treatment modalities, tuberculous (TB) lymphadenitis still remains a major health problem in developing countries. In India, extrapulmonary TB accounting 20% of all TB cases...
Evaluation of Computed Tomography Guided Percutaneous Fine Needle Aspiration Cytology in the Diagnosis of Lung Lesions
Introduction: Computed Tomography (CT) guided percutaneous fine-needle aspiration cytology (FNAC) of suspicious lung lesions is a widely accepted diagnostic method with relatively low cost, negligible mortality and limit...
Histopathological Study of Tumours of Epidermis and Epidermal Appendages
Introduction: Skin is a complicated protective covering [1]. It is divided into two seemingly separate but functionally interdependent layers, i.e., epidermis and dermis. Adnexae extend from epidermis into the dermis and...