Screening of Antianxiety Activity of Habenaria Intermedia D. Don Fruits
Journal Title: JOURNAL OF PHARMACEUTICAL TECHNOLOGY, RESEARCH AND MANAGEMENT - Year 2017, Vol 5, Issue 1
Abstract
Habenaria intermedia D. Don (Vriddhi; Orchidaceae) has been traditionally used in the treatment of nervous disorders, skin disorders and asthma. The available pharmacological reports on H. intermedia reveal that the plant has not been screened for antianxiety activity. Thus, it was envisaged to subject H. intermedia for screening of antianxiety activity using elevatedplus maze model. The crude extracts (n-hexane, chloroform, methanol and water extracts) of plant material were prepared successively in increasing order of polarity. The anxiolytic activity was assessed by comparing number of entries and average time spent by mice treated with test extracts (200 or 400 mg/kg, p.o.) in open arms of EPM with respect to control and standard drug, diazepam (2 mg/kg, p.o.). Significant antianxiety activity was observed in methanol extract with respect to control, whereas n-hexane, chloroform and water extracts did not exhibit antianxiety activity. It is further observed that antianxiety activity exhibited by the methanol extract was statistically not equivalent to the standard drug. Based on these observations, it is concluded that the methanol extract of H. intermedia exhibits mild anxiolytic activity.
Authors and Affiliations
Pawan Kumar , Reecha Madaan , Shabir Sidhu
Keywords
Related Articles
- EP ID EP596724
- DOI 10.15415/jptrm.2017.51006
- Views 138
- Downloads 0
Evaluation of Polyherbal Anticancer Tablets: A Review
Cancer is a malignant abnormal growth of cells, one of the most dreaded and complex diseases. It concerns with several tempo spatial changes in cell composition, which finally lead to neoplasia. Various types of cancers...
Investigation of the Effects of Cellulose Derivatives on the Kinetics of Drug Release from Cellulose-Based Hydrogel Using a Response Surface Method
The aim of this work was to investigate the effects of the nature and concentration of cellulose derivatives on the release kinetics of ibuprofen from hydrogel matrices using a response surface method (RSM). A series of...
Formulation, Optimization and Evaluation of Sustained Release Microspheres using Taguchi Design
The aim of present study is to prepare microspheres of eudragit RL 100 loaded with Nefopam Hydrochloride by single emulsion solvent evaporation technique. Taguchi L9 orthogonal array design has been used to optimize the...
Development, physicochemical characterization and in-vitro evaluation of herbal sunscreen lotion
Ultraviolet radiations have shorter wavelengths and can reach earth’s surface through penetrating clouds. UV-A rays leads to aging while UV-B rays causes burning of skin. Sunscreens protect the skin from harmful effects...
Development and Validation of Static HS-GC Method for the Determination and Quantification of Residual Solvents of Bromhexine Hydrochloride (BHX)
The determination of residual solvents in drug substances is the mandatory requirement by various health authorities in the world. There are no analytical methods available in the literature that can simultaneously separ...