Screening of bioactives, anti-oxidant and anti-cancer potential of a herbal formulation
Journal Title: International Journal of Advanced Biochemistry Research - Year 2018, Vol 2, Issue 2
Abstract
Medicinal plants have a role in cancer management. The purpose of this study was to develop a herbal adjunct for symptom management in cancer treatment and evaluate its in vitro antioxidant and anti-cancer activity. Locally available and traditionally used medicinal plants with known anti-cancer properties were selected for development of the formulation. Two variations of the formulation viz., Raw herbal formulation (RHF) and Heat treated formulation (HTF) were prepared. The activity of the variations was compared with Triphala (TRF). The 80% methanol extract of all the samples exhibited higher antioxidant activity and was chosen for screening the anti-cancer ability. The results of GC-MS showed that bioactives having potential anti-cancer effect were identified in HTF with lower probability. However, bioactive components with anti-oxidant, anti-cancer, anti-tumor and cyto-toxic activity were higher in RHF. The morphological studies confirmed apoptotic effect of RHF. Overall, RHF exhibited higher in vitro antioxidant, anti-cancer and cytotoxicity effect.
Authors and Affiliations
Maithri Mohan, Namratha Pai Kotebagilu, Lohith Mysuru Shivanna, Shailasree Sekhar, Uliyar Vitaldas Mani, Asna Urooj
Keywords
Related Articles
- EP ID EP529550
- DOI -
- Views 38
- Downloads 0
Human chorionic gonadotropin levels as a biochemical markers in pregnancy induced hypertension
Pregnancy Induced Hypertension and its sequel are severe complications of pregnancy. The prognostic significance of high levels of serum free β-hCG in early pregnancy for subsequent obstetric and perinatal risks is still...
Chemical investigation of Pomegranates and Its Health Benefits
In this paper, the chemical investigation and medicinal properties of Punica granatum L. (Punicaceae) have been noticed. In the past years, studies on the antioxidant, anticarcinogenic, and anti-inflammatory properties o...
Evaluating the nutritional value and shelf life of fish patty enriched with protein concentrate from Abramis brama at ambient temperature
In recent decades, because of the increased population and the importance of animal protein, the production of high value added products from marine resources has attracted much attention. On the other hand, protein defi...
Review of Epidemiology, Diagnosis, Control, Therapeutics and Vaccine development for Crimean-Congo Hemorrhagic Fever
Crimean-Congo Hemorrhagic Fever (CCHF), among the high-priority pathogens because of its high case fatality rate and its potential for nosocomial outbreaks and the subsequent difficulties in treatment and prevention. For...
Inflammatory markers in essential hypertension
Hypertension (HTN) is now a major health problem in India. Both environmental and genetic factors may contribute to regional and racial variations of blood pressure (B.P.) and hypertension prevalence. Obesity and weight...