Search for drugs of the combined anti-inflammatory and anti-bacterial properties: 1-methyl-N'-(hydroxymethyl)nicotinamide.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 2
Abstract
It has already been reported that 1-methylnicotinamide (MNA(+)), a primary metabolite of nicotinamide (vitamin B(3)), possesses remarkable anti-inflammatory properties [3]. This communication shows that 1-methyl-N'-(hydroxymethyl)nicotinamide (MNAF(+) can be regarded as MNA(+) precursorable to release simultaneously formaldehyde. Therefore, MNAF(+) can be viewed as a candidate for drug with the combined anti-inflammatory and anti-bacterial properties.
Authors and Affiliations
Maciej Adamiec, Jan Adamus, Ireneusz Ciebiada, Andrzej Denys, Jerzy Gębicki
Keywords
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