Secondary Metabolites of Hypericum L. Species as Xanthine Oxidase Inhibitors - - - Inhibicija ksantin-oksidaze sekundarnim metabolitima iz biljnih vrsta roda Hypericum L.
Journal Title: Acta Facultatis Medicae Naissensis - Year 2017, Vol 34, Issue 4
Abstract
Nine Hypericum species (H. barbatum, H. hirsutum, H. linarioides, H. olympicum, H. perforatum, H. rochelii, H. rumeliacum, H. tetrapterum and H. umbellatum) collected in Serbia were assayed for inhibitory potential against xanthine oxidase in vitro, on the commercial enzyme, and compared with allopurinol. Seven studied Hypericum species (H. barbatum, H. rochelii, H. rumeliacum, H. umbellatum, H. perforatum, H. tetrapterum and H. olympicum) inhibit commercial xanthine oxidase with an IC50 below 100 μg/mL. H. barbatum exerted the most potent inhibitory effect (IC50 = 31.84 ± 6.64 μg/mL), followed closely by H. perforatum (IC50 = 37.12 ± 4.06 μg/mL). - - - I spitan je uticaj devet Hypericum vrsta (H. barbatum, H. hirsutum, H. linarioides, H. olympicum, H. perforatum, H. rochelii, H. rumeliacum, H. tetrapterum i H. umbellatum) prikupljenih na području Srbije na aktivnost komercijalne ksantin-oksidaze in vitro i upoređena sa alopurinolom. Sedam ispitivanih Hypericum vrsta (H. barbatum, H. rochelii, H. rumeliacum, H. umbellatum, H. perforatum, H. tetrapterum i H. olympicum) inhibiraju komercijalnu ksantin-oksidazu sa IC50 vrednostima nižim od 100 μg/mL. H. barbatum (IC50 = 31,84 ± 6,64 μg/mL) i H. perforatum (IC50 = 37,12 ± 4,06 μg/mL) su se pokazali kao najefikasniji inhibitori ksantin-oksidaze
Authors and Affiliations
Andrija Šmelcerović, Žaklina Šmelcerović, Katarina Tomović, Gordana Kocić, Aleksandra Djordjević
Keywords
Related Articles
- EP ID EP348773
- DOI 10.1515/afmnai-2017-0029
- Views 70
- Downloads 0
MULTISLICE COMPUTED TOMOGRAPHY (MSCT) APPLICATION IN THE DIAGNOSIS OF CORONARY ARTERY DISEASE
Coronary computed tomography angiography (CTA) is the first non-invasive imaging technique that allows the evaluation of the lumen and walls of the coronary arteries. The sensitivity in defining significant stenosis (>...
Congenital Posteromedial Bowing of the Tibia: A Single Center Experience - - - Kongenitalna posteromedijalna angulacija tibije: iskustva jednog centra
Congenital posteromedial bowing of the tibia (CPMBT) is a rare congenital anomaly of the lower limbs. The aim of the present study was to analyze our experience in the treatment of CPMBT. A retrospective study of patient...
REKURENTNA MALIGNA HIPERTENZIJA LEČENA BLOKATOROM RECEPTORA ANGIOTENZINA II (ARB) I ACE INHIBITOROM
Prognoza maligne hipertenzije bez lečenja je loša, sa više od 80% mortaliteta u periodu od dve godine. Nije uobičajeno da se vidi više od jednog puta kod istog bolesnika. U radu su predstavljeni klinički tok, odgovor na...
Topical Anesthetic Misuse in Patients Admitted to Sabzevar Eye Clinic in Iran - - - Nepravilna upotreba topikalnih anestetskih kapi za oči kod bolesnika primljenih na očnu kliniku u Sabzevaru u Iranu
Topical anesthetic eye drops are used extensively for ophthalmic examinations but self-treatment and non-technical removal of foreign bodies using tetracaine drops can be hazardous. The present study intended to determin...
An Outbreak of Human Trichinellosis in the Village of Subotinac near the Town of Aleksinac - - - Epidemija humane trihineloze u selu Subotinac u okolini Aleksinca
An outbreak of trichinellosis affecting 13 individuals, of whom 8 with severe form presented as myocarditis, occurred in the village of Subotinac near the town of Aleksinac in Serbia. The source of this epidemic was smok...