Secondary Metabolites of Hypericum L. Species as Xanthine Oxidase Inhibitors - - - Inhibicija ksantin-oksidaze sekundarnim metabolitima iz biljnih vrsta roda Hypericum L.
Journal Title: Acta Facultatis Medicae Naissensis - Year 2017, Vol 34, Issue 4
Abstract
Nine Hypericum species (H. barbatum, H. hirsutum, H. linarioides, H. olympicum, H. perforatum, H. rochelii, H. rumeliacum, H. tetrapterum and H. umbellatum) collected in Serbia were assayed for inhibitory potential against xanthine oxidase in vitro, on the commercial enzyme, and compared with allopurinol. Seven studied Hypericum species (H. barbatum, H. rochelii, H. rumeliacum, H. umbellatum, H. perforatum, H. tetrapterum and H. olympicum) inhibit commercial xanthine oxidase with an IC50 below 100 μg/mL. H. barbatum exerted the most potent inhibitory effect (IC50 = 31.84 ± 6.64 μg/mL), followed closely by H. perforatum (IC50 = 37.12 ± 4.06 μg/mL). - - - I spitan je uticaj devet Hypericum vrsta (H. barbatum, H. hirsutum, H. linarioides, H. olympicum, H. perforatum, H. rochelii, H. rumeliacum, H. tetrapterum i H. umbellatum) prikupljenih na području Srbije na aktivnost komercijalne ksantin-oksidaze in vitro i upoređena sa alopurinolom. Sedam ispitivanih Hypericum vrsta (H. barbatum, H. rochelii, H. rumeliacum, H. umbellatum, H. perforatum, H. tetrapterum i H. olympicum) inhibiraju komercijalnu ksantin-oksidazu sa IC50 vrednostima nižim od 100 μg/mL. H. barbatum (IC50 = 31,84 ± 6,64 μg/mL) i H. perforatum (IC50 = 37,12 ± 4,06 μg/mL) su se pokazali kao najefikasniji inhibitori ksantin-oksidaze
Authors and Affiliations
Andrija Šmelcerović, Žaklina Šmelcerović, Katarina Tomović, Gordana Kocić, Aleksandra Djordjević
Keywords
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- EP ID EP348773
- DOI 10.1515/afmnai-2017-0029
- Views 76
- Downloads 0
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