SELECTED PHARMACEUTICAL PROPERTIES OF THERMOSENSITIVE HYDROPHILIC GELS WITH HYDROXYPROPYLMETHYLCELLULOSE CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2013, Vol 0, Issue
Abstract
Gels containing lactic acid complexed with chitosan at a stoichiometric ration 1:1 and 2:1 and 5 - 25% content of polyoxyethylene glycol 200 are able to move from 25 to 30 cm. The addition of 4% hydroxypropylmethylcellulose besides glycerol increases the movability gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 from 25 cm to 28 cm and at 2:1 ratio from 27 cm to 30 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 24 to 29 cm The addition of 5 - 25% glycerol decreases the pH of investigated gels from 3.95 to 4.45 (1:1) and from 3.63 to 4.30 (2:1). The addition of 5 - 25% 1,2-propylene glycol decreases the pH of investigated gels from 4.00 to 4.46 (1:1) and from 3.70 to 4.33 (2:1). The use of hydroxypropylmethylcellulose allowed to obtain physiological range. The addition of hydroxypropylmethylcellulose reduces the pH and maintains high adhesion.
Authors and Affiliations
Katarzyna Małolepsza-Jarmołowska
Keywords
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- EP ID EP73502
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