Selective Androgen Receptor Modulators (SARMs): A Mini-Review
Journal Title: Open Access Journal of Reproductive System and Sexual Disorders - Year 2018, Vol 1, Issue 1
Abstract
Selective Androgen Receptor Modulators (SARMs) were discovered in the late 1990’s.They may have an application in treatments of various diseases, including muscle wasting, cancer cachexia, breast cancer, osteoporosis, andropause and sarcopenia. In this minireview the development, pharmacodynamics, and the phase 1 and 2 trial results of the SARMs are discussed with a special emphasis on the illicit use of the SARMs. The androgen receptor (AR) is a member of the steroid hormone receptor family that plays important roles in the physiology and pathology of diverse tissues.AR ligands,which include circulating testosterone and locally synthesized dihydrotestosterone bind to activate the AR to elicit their effects.Ubiquitous expression of the AR metabolism and cross reactivity with other receptors limit broad therapeutic utilisation of steroidal androgens.However,the discovery of selective androgen receptor modulators (SARMs) provide an opportunity to promote the benificial effects with greatly unwanted side effects. In the last two decades SARMs have been proposed as treatments of choice for various diseases, including muscle wasting, breast cancer and osteoporosis. In addition, they may have an application in andropause, sarcopenia, cancer cachexia and as selective anabolic steroids in performing body building sports [1-6]. In this mini-review the development, pharmacodynamics and the phase 1 an2 trial results of the SARMs are discussed,with a special emphasis on the illicit use of the SARMs.
Authors and Affiliations
Michael AB Naafs
Keywords
Related Articles
- EP ID EP635017
- DOI 10.32474/OAJRSD.2018.01.000103
- Views 116
- Downloads 0
Preliminary Results with Technical Considerations of Video-Assisted Anal Fistula Treatment (VAAFT)- The First Experience in Bangladesh
Most anorectal fistula represents an epithelised communication path of infectious origin between the rectum or anal canal and the perianal region. The association of endoscopic surgery with the minimally invasive approac...
Nonmosaic Klinefelter Syndrome Successful Conception after TESE/ICSI: A case report
Klinefelter syndrome patients are mostly clinically azoospermic, and before the era of TESE, were unable to father genetically their own offspring. Nonmosaic Klinefelter [NMK] patients have chances of fatherhood once spe...
Expression of the Chemokine CXCL12 and its Receptors CXCR4 and CXCR7 in Human and Nonhuman Primate Uterine Leiomyomas
Uterine leiomyomas (also known as fibroids) are associated with several symptoms, including abnormal uterine bleeding, pressure-related symptoms, and recurrent pregnancy loss. These tumors affect up to 80% of fertile wom...
Sleep Disorders in Perimenopausal Women and Metabolic Syndrome, is that True?
Sleep disorders (SD) are a common complaint in women going through menopause transition. It is well known that there is a close relationship between SD and one of the main menopausal sympto...
Challenges in the Treatment of Vasomotor Symptoms:Update in Non-Hormonal Strategies
Perimenopause and menopause per se significantly impacts on women quality of life (QoL), especially due to vasomotor symptoms (VMS); their duration is uncertain, and often long. Although menopause hormone therapy (MHT) i...