Serologic status at 10 months of infants born to hepatitis B positive mothers given prophylaxis - A prospective cohort study
Journal Title: Indian Journal of Child Health - Year 2017, Vol 4, Issue 3
Abstract
Rationale: Perinatal exposure is the most common mode of transmission of hepatitis B (HB) infection in neonates. Prevention of perinatal transmission of HB is important to decrease overall carrier state. Objectives: To estimate the rate of HB carrier status among children born to HB surface antigen (HBsAg) positive mothers at 10 months of age measured by HBsAg status and to assess the efficacy of prophylaxis (HB vaccine [HBV] and HB immunoglobulin [HBIG] administration) as measured by the anti-HBs titer at 10th month of age. Methodology: This was a hospital based prospective cohort study of infants born to HBsAg positive mother between April 2008 and October 2008 with a follow-up at 6 weeks, 14 weeks, and 10 months of age. After informed consent from the parents, 0.5 ml of recombinant vaccine was given to all. HBIG was given to only those who could afford to buy it. At 6 and 14 weeks of age, 0.5 ml of recombinant vaccine was given according to the IAP immunization schedule along with other UIP vaccines to all neonates. At 10 months of age (plus 1 week), 69 infants completed 3 doses of HBV. Anti-HBs titer and HBsAg status were measured. Anti-HBs titer >100 IU/L was taken as a good responder. Results: Total 125 infants were initially recruited. All were vaccinated with HBV within 12 h of birth. HBIG was given to 96 infants (76.8%) and only 69 (55.2%) completed 3rd visit. Carrier state in infants born to HBsAg positive mothers at 10 months of age was 1/69 (1.44%). 43/69 (62.35%) had good antibody response out of which, 41 were given both HBV and HBIG. In those given only vaccine, 2/7 (28.55%) had good antibody response (p=0.02). Conclusion: Combined HB vaccine and immunoglobulin had a better antibody response in the study as reported earlier. The carrier state was 1.44%.
Authors and Affiliations
Geetha Saradakutty, C Dharmarajan, A Santhosh Kumar
Keywords
Related Articles
- EP ID EP456515
- DOI -
- Views 74
- Downloads 0
Bacteriological analysis of donor human milk in milk bank in an Indian setting
Background: Although human milk banking in India was started in 1984, limited data regarding bacteriological quality of milk are available. Objective: To find bacteriological contamination of milk samples in human milk b...
Role of oral erythromycin for feed intolerance in neonates - A randomized controlled trial
Objective: The objective of this study was to compare the effect of high and low dose of erythromycin with placebo and to determine the efficacy and safety of oral erythromycin for feed intolerance in neonates admitted t...
Effect of Vitamin D supplementation in under-5 children with pneumonia: A randomized controlled trial
Objective: The objective of the study was to study whether Vitamin D supplementation in under-5 children presenting with pneumonia and severe pneumonia reduces its duration and recurrences. Study Design: This study was d...
Staphylococcal scalded skin syndrome in a very low birth weight preterm infant
Staphylococcal scalded skin syndrome (SSSS) is an exfoliative dermatitis produced by the toxins of some strains of staphylococci, predominantly phage Group 2, strains 71 and 55. It has been reported mostly in children un...
Evaluation of vaccination status of children attending a private tertiary paediatric hospital in urban Hyderabad
Objectives: The objectives of this study were to understand the vaccination status and reasons for missed vaccination in the catchment of a tertiary private paediatric hospital in a densely populated area in urban Hydera...