SEROPOSITIVITY OF H. PYLORI AMONG DYSPEPTIC PATIENTS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 17
Abstract
BACKGROUND H. pylori infection affects nearly half of the world’s population. In developing countries, the prevalence of infection is as high as 90%. Various diagnostic tests (invasive and non-invasive) are available to detect H. pylori infections. The invasive tests include histology, rapid urease test, culture and PCR; while non-invasive tests include serology (qualitative and quantitative IgG), urea breath test and stool antigen assay. Aims and Objectives- In this study, we evaluated the prevalence of H. pylori among patients with dyspepsia visiting our hospital using the Helicobacter pylori IgG antibody test kit (Demeditec Diagnostics, Germany). The test kit is based on the principle of the enzyme immunoassay (EIA). MATERIALS AND METHODS This is a hospital-based observational study from January 2015 to August 2017. Serum samples of 1980 patients (both inpatients and outpatients) with dyspepsia/ non-specific pain abdomen were included in this study. Immunoglobulin G (IgG) antibody to H. pylori is detected using a commercial kit (Demeditec Diagnostics, Germany). RESULTS Of 1980 patients 1907 (96.32%) were adults (> 16 years of age), while the remaining 73 (3.68%) were from paediatric age group. Among adults the seropositivity of H. pylori was seen in 42.73% (815 out of 1907), while paediatric group had seropositivity of 17.80% (13 out of 73 patients). CONCLUSION Serological testing can be used as a screening test for initial evaluation of dyspeptic patients. Serological tests avert UGI endoscopy in many, thus reducing the cost of treatment burden on patients and at the same time reducing endoscopy load on the specialist. The serological test is cost effective, easily available and rapid
Authors and Affiliations
Shavi Nagpal, Aroma Oberoi, Navjot Singh
Keywords
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- EP ID EP415107
- DOI 10.14260/jemds/2018/460
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