Seroprevalence of C - Reactive Protein in Rheumatoid Arthritis Cases: A Retrospective Study in a Tertiary Care Hospital in South India
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 11
Abstract
Abstract: Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune inflammatory disease that affects mainly the small joints of the hands and feet. It is one of the most common inflammatory joint diseases that compromise quality of life, cause disability and even premature mortality. RA is widely prevalent throughout the world, mainly affecting older women. Clinical manifestations consist of pain, swelling and tenderness of the small joints of the hands. Since RA is a systemic disease, patients may have accompanying constitutional symptoms such as fever, weight loss and fatigue. At initial patient evaluation complete blood count including ESR, liver function tests, kidney function tests, and CRP should be done. CRP (C-reactive protein) is an important biomarker of inflammation in RA which can help to monitor disease progression. Rheumatoid factor (RF) is detectable during the course of disease in approximately 75% to 85% of patients with RA. High titres of RF are associated with aggressive, destructive joint disease and extra-articular complications such as interstitial lung disease and rheumatoid vasculitis. The present study was undertaken to retrospectively analyse the prevalence of RF and association with CRP in patients presenting to a tertiary care hospital in South India. Of the 631 sera specimens submitted for RF test, 34 were positive i.e. there was 5.4% seroprevalence of RF in the study population. Majority of the cases i.e. 73% were females; 44% of RF positive patients were in the age group of 21-40 years, followed by 35% in the 41-60 years age group. Among the RF seropositive patients, elevated CRP levels were found in 41% of the cases. Thus the role of CRP as an acute inflammatory marker and important diagnostic indicator in RA is confirmed by the results of our study.
Authors and Affiliations
Dr. S. Nikhat Sheerin, Dr. Mohammed Nasaruddin, Dr. V. V. Shailaja, Dr. K. Nagamani
Keywords
Related Articles
- EP ID EP479178
- DOI -
- Views 51
- Downloads 0
Synthesis and Antioxidant Activity of Mixed Ligand Complex of Quercetin and Aspartic Acid with Cobalt (II)
Abstract: Mixed ligand complexes are widely used in the field of pharmaceutical science due to their curing nature to various diseases. The present study was aimed to synthesize and explore the antioxidant activity of co...
Study of Bone marrow aspiration and biopsies in Pancytopenia – A study on 48 patients
Abstract: Pancytopenia is a relatively common entity. However, it has received inadequate attention in the Indian subcontinent. A study of pancytopenia using easily available diagnostic techniques is therefore relevant....
A Comparative study of the Socio demographic and activity profile of elderly residing in Old Age Homes and in the Community of Rajkot, Gujarat, India
Abstract: The world population is rapidly ageing. Between 2000 and 2050, the proportion of the world’s population aged over 60 years will double from 11% to 20%. In the absence of joint family system and nuclearisation o...
Psoriatic Arthritis A Systematic Review
Psoriatic arthritis is an inflammatory disorder of unknown etiology generally with negative rheumatoid factor and associated with patients having psoriasis. The prevalence of uncomplicated psoriasis is between 1-3% in th...
Serum gastrin level estimation, is it a prognostic indicator in operated carcinoma stomach patients?
Abstract: Inspite of substantial geographic variation, gastric carcinoma still continues to be one of the most common tumours worldwide. Variants of tumour markers have been and are being established for diagnosis of gas...