Seroprevalence of C - Reactive Protein in Rheumatoid Arthritis Cases: A Retrospective Study in a Tertiary Care Hospital in South India
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 11
Abstract
Abstract: Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune inflammatory disease that affects mainly the small joints of the hands and feet. It is one of the most common inflammatory joint diseases that compromise quality of life, cause disability and even premature mortality. RA is widely prevalent throughout the world, mainly affecting older women. Clinical manifestations consist of pain, swelling and tenderness of the small joints of the hands. Since RA is a systemic disease, patients may have accompanying constitutional symptoms such as fever, weight loss and fatigue. At initial patient evaluation complete blood count including ESR, liver function tests, kidney function tests, and CRP should be done. CRP (C-reactive protein) is an important biomarker of inflammation in RA which can help to monitor disease progression. Rheumatoid factor (RF) is detectable during the course of disease in approximately 75% to 85% of patients with RA. High titres of RF are associated with aggressive, destructive joint disease and extra-articular complications such as interstitial lung disease and rheumatoid vasculitis. The present study was undertaken to retrospectively analyse the prevalence of RF and association with CRP in patients presenting to a tertiary care hospital in South India. Of the 631 sera specimens submitted for RF test, 34 were positive i.e. there was 5.4% seroprevalence of RF in the study population. Majority of the cases i.e. 73% were females; 44% of RF positive patients were in the age group of 21-40 years, followed by 35% in the 41-60 years age group. Among the RF seropositive patients, elevated CRP levels were found in 41% of the cases. Thus the role of CRP as an acute inflammatory marker and important diagnostic indicator in RA is confirmed by the results of our study.
Authors and Affiliations
Dr. S. Nikhat Sheerin, Dr. Mohammed Nasaruddin, Dr. V. V. Shailaja, Dr. K. Nagamani
Keywords
Related Articles
- EP ID EP479178
- DOI -
- Views 58
- Downloads 0
Prediction of Prostate Cancer by Analyzing of Serum Trace Elements
Abstract: Worldwide 1.1 million men were diagnosed with prostate cancer in 2012. In India, it is the second most widespread cancer in Indian males. Despite the far-reaching experimental and clinical studies over decades,...
The Effect of Relaxation Training on the Pain after Surgery in 8-12 year old Children admitted to the Surgical Units of Shiraz University of Medical Sciences in 1393-94
Abstract: Pain is one of the common problems after surgery in children that non-pharmacological methods of pain relief have been useful in some forms of the pain but the impact of these techniques, such as relaxation the...
Cytomorphological Study of Benign Breast Lesions by FNAC
A major clinical problem of women in reproductive age groups is benign breast lesion. Fine needle aspiration cytology (FNAC) plays an important role in diagnosing these breast lesions. In the present study cytomorphologi...
A Study of Pulmonary Function Test in Asymptomatic Smokers
Abstract: Smoking is a pernicious scourge of the world today. Smoking is well known to increase the risk of the risk of pulmonary diseases by affecting the pulmonary functions. Hence, emphasis should emphasis should be p...
CSOM: Atticoantral Disease- Role of Microbes
Abstract: Chronic Suppurative Otitis Media (CSOM) is one of the common otological problems in our community with many intracranial and extracranial complications. In view of probable role of microorganisms we have carrie...