Serotype-Specific Pneumococcal Status prior to PCV 13 Administration in Children and Adolescents with Inflammatory Bowel Disease
Journal Title: Polish Journal of Microbiology - Year 2016, Vol 65, Issue 1
Abstract
The aim of this study was to evaluate the serotype-specific pneumococcal status of children and adolescents with inflammatory bowel disease (IBD) who were naïve to pneumococcal vaccination before administering the 13-valent pneumococcal conjugate vaccine (PCV 13). This was an open, prospective study on children and adolescents aged 5–18 years who had IBD and were naïve to pneumococcal vaccination. A single dose of PCV 13 was administered to each patient. The geometric mean concentrations (GMCs) were measured for all 13 serotypes. A total of 122 subjects completed the study. Prevaccination GMCs ranged from 0.55 μg/ml (serotype 4) to 4.26 μg/ml (serotype 19A). Prior to the administration of PCV 13, high GMCs were detected in older children and adolescents who had IBD and were naïve to pneumococcal vaccination.
Authors and Affiliations
Aleksandra Banaszkiewicz, Brygida Targonska, KInga Kowalska-Duplaga, Katarzyna Karolewska-Bochenek, Agnieszka Sieczkowska, Urszula Grzybowska-Chlebowczyk, Elzbieta Krzesiek, Izabella Lazowska-Przeorek, Maria Kotowska, Edyta Sienkiewicz, Jaroslaw Walkowiak, Hanna Gregorek, Andrzej Radzikowski, Piotr Albrecht
Keywords
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