Serrum ferritin: A prognostic marker in patients with sepsis in Pediatric age group: A prospective cohort study
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 3
Abstract
Objectives: To determine serum ferritin value, to study its correlation with PRISM/PELOD score and mortality in patients with sepsis. Methods: This Analytical Observational prospective cohort study was done in12-bedded Pediatric intensive care unit (PICU) of Sir Ganga Ram Hospital, New Delhi. 149 patients with sepsis were included for the study with an inclusion criteria of age >28 days or <16 years and PICU stay >24 hours. Serum ferritin was collected at the time of diagnosis of sepsis. Patient demographics were noted and Pediatric risk of mortality (PRISM) score and Pediatric logistics dysfunction (PELOD) score were calculated. All patients were followed up throughout their hospital stay and outcome data (survival or mortality) was obtained. Results: Of the 149 patients, 93 survived while 56 died in PICU. Non survivors had a significant higher median ferritin (1205.50 ng/ml) as compared to survivors (p < 0.001). At a cut off of 1100 ng/ml, serum ferritin was associated with a 2.3 (1.571-3.614) relative risk (p < 0.0001) for predicting mortality in patients with sepsis. PRISM and PELOD score were independently associated with mortality and also had a weak correlation with serum ferritin value. No significant difference was found in C- reactive protein (CRP) as well as procalcitonin value in survivors and non survivors group. Conclusion: High serum ferritin level is associated with poor outcome in patients of sepsis and can be used as a predictive marker of mortality along with current prognostic scores.
Authors and Affiliations
Dr. Jyoti Sharma, Dr. Roop Sharma
Keywords
Related Articles
- EP ID EP584577
- DOI -
- Views 114
- Downloads 0
Laser assisted management of pyogenic granuloma of unusual size: A case report
Pyogenic granuloma is a non-neoplastic inflammatory hyperplasia which is also known as ‘Lobular Capillary Hemangioma’. Gingiva is the most commonly affected site for oral pyogenic granuloma followed by tongue, hard palat...
Antioxidant activity of superoxide dismutase in relation to the neurological complications in diabetes mellitus
Aim: The antioxidant activity of superoxide dismutase (SOD) was evaluated with the duration of neurological problems like poly/sensory neuropathy due to diabetes. Material and Method: The study was conducted with 55 diab...
Flaxseed subsides biological markers in cancer breast: A study
Lignans are compounds found in a variety of plant materials including flaxseed, pumpkin seed, sesame seed, soybean, broccoli, and some berries. The major lignan in flaxseed is called secoisolariciresinol diglucoside (SDG...
Evaluation of latex agglutination test (LAT) and efficacy in diagnosis of pyogenic meningitis in children
Pyogenic meningitis is one of the most common and devastating disease of Central Nervous System, especially in children. We carried out an observational study with the aim was Evaluation of Latex Agglutination Test Effic...
Antimicrobial resistance pattern in Enterococcus species and detection of vanA gene among vancomycin resistant isolates in a tertiary care hospital
Background: Since late 1980s, emergence of vancomycin (a glycopeptide) resistance has been observed among Enterococcal isolates worldwide. Glycopeptide resistance in Enterococci has been dealt with in a few studies in In...