Serum Alkaline Phosphatase, A Prospective Biomarker For Assessment of Progress of Fracture Healing
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 12
Abstract
Introduction: Bone-specific alkaline phosphatase is a specific marker of osteoblasts and gives a good measure of bone forming activity.1 bone metabolic units (BMU )are also activated in fracture healing and can be demonstrated quantitatively by estimation of bone turnover markers (BTMs). Serum alkaline phosphatase is a specific marker of osteoblasts and gives a good measure of bone forming activity. Aims :to evaluate the changes in serum alkaline phosphatase levels during healing of isolated femur shaft fractures treated with close reduction and interlocking nail Material And methods: descriptive, prospective and follow up study was conducted in the department of Orthopaedics, SMS Medical College & Attached Hospitals, Jaipur.64 healthy adults of age 18 to 45years with isolated closed fracture femur were included. The patients with any systemic condition, disease, and/or drug intake affecting bone turnover in any manner were excluded from the study. The fractures were closed reduced and internally fixed using an interlocking nail. Allthe patients were followed up every month for 9 months after injury to look for clinico-radiological signs of fracture union. Biochemical monitoring was done The marker ALP was measured using in vitro qualitative measurement by p-NPP method in biochemistry lab. Results: The outcome of the current study is that the serum alkaline phosphastase is suggested as non-invasive aids for monitoring fracture healing. It may help in the monitoring of fracture healing, complementing the clinico-radiological evaluation. The detection of volume of callus formed across the fracture site in combination with clinical signs of union remain the gold standard for assessing fracture healing. But early detection of a slow healing or a non-healing fracture is not possible using these methods only. Conclusion: sustained efforts need to be continued in our endeavour to find a bone turnover marker as a diagnostic or prognostic tool for monitoring bone healing
Authors and Affiliations
Dr. Anand Prakash, Dr. Nutan verma, Dr. M. P. Goyal, Dr. Narendra joshi, Dr. Mukesh Saini
Keywords
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- EP ID EP250435
- DOI 10.9790/0853.1612012733
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