Serum and urinary β-glucuronidase in acute alcohol intoxication: a pilot study
Journal Title: Progress in Health Sciences - Year 2012, Vol 2, Issue 2
Abstract
Introduction: Beta-glucuronidase (GLU) is a member of the lysosomal glycosidase family that catalyzes hydrolysis of β-D-glucuronic acid residues from the non-reducing end of glycosaminoglycans. Increased activities of GLU have been earlier reported in the serum of alcohol-dependent patients after a chronic heavy drinking period but not after acute intoxication (called binge drinking). The accelerating binge drinking pheno-menon is an alarming public health issue that requires better prevention. Purpose: To determine the activity serum and urinary GLU, after an acute, single, and a large dose of alcohol intoxication. Materials and methods: The serum and urine of eight healthy binge drinkers were collected before binge drinking, and 2 and five days after the drinking session. The activity of GLU was determined by the colorimetric method. Results: There was a tendency to decrease in the serum GLU activity two days after acute alcohol intoxication (binge drinking), which was followed by the significant increase in the GLU activity five days after drinking. The urinary activity of GLU was not changed after intoxication. Conclusion: Alcohol-induced imbalance in the serum GLU activity might be associated with alcohol-induced liver hypoxia and subsequent reperfusion, and can be detected even five days after the drinking session.
Authors and Affiliations
N Waszkiewicz, B Zalewska-Szajda, A Buras, K Zwierz, JR Ładny, SD Szajda
Keywords
Related Articles
- EP ID EP75767
- DOI -
- Views 90
- Downloads 0
Smoking and substance abuse among nurses in Turkey: A systematic literature analysis
Background: It is necessary that physicians, nurses, other health professionals and even medical students and students of nursing and midwifery schools abstain from smoking. Those who are already smokers should quit or m...
Transmucosal in addition to transdermal fentanyl, administered in exacerbations of cancer pain, does not change the emotional status of patients
Introduction: Opioids, regardless of the route of administration, are essential analgesics for the treatment of cancer pain. The transmucosal route of fentanyl administration is a relatively new but widely used technique...
Satisfaction with nursing care provided to patients who have undergone surgery for neoplastic disease
Purpose: To investigate satisfaction of cancer patients, who have undergone cancer surgery, with nursing care and the association of patient satisfaction with demographic and clinical characteristics. Materials and metho...
The oncoprotein HBXIP – its functions and roles in oncogenesis
Nowadays, Hepatitis B X interacting protein (HBXIP) is an object of scientists’ interest worldwide. It is a protein with significant involvement in the development of malignant tumors like breast or ovarian cancer. One o...
DIPNECH – a preneoplastic lesion or a separate biological entity?
Introduction: DIPNECH is a very rare condition with under 100 cases reported in the scientific literature worldwide. The new WHO classification of lung tumors considers it as a preneoplastic condition, leading to further...