Serum C reactive protein levels in metabolic syndrome
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 9
Abstract
Abstract:CRP is a major acute phase protein it is a very sensitive marker of tissue damage and tissue inflammation. Recent evidences have shown that CRP levels increases in metabolic syndrome, with this background we in the present study tried to evaluate the levels of CRP in subjects with metabolic syndrome.The study was conducted in the Department of Biochemistry Rajiv Gandhi Institute of Medical Sciences, [RIMS] Adilabad. The study involved 50 adult male aged 30-45 yrs, they were divided into two groups, Group I [test group] (n=25) The Group II [control group] (n=25) included normal age and sex matched patients serving as controls. 10 ml of blood was withdrawn from the large peripheral vein in a container for biochemical evaluation. Blood sugar estimation was done and from the remaining sample serum was separated by centrifugation and stored at a temperature of 4-8°C till the tests were done that included Serum Uric acid, Triglycerides, and hs-CRP. The mean BMI of Group I was 29.84 ± 1.86 and 22.9 ± 1.23, the p value was found to be significant. In order to determine abdominal obesity, we used Waist Hip Ratio [WHpR], with a value of above 0.9 was considered as the marker of abdominal obesity. The Group I had mean values of [WHpR] was 1.0 ± 0.09 and the Group II was 0.84 ± 0.03. The mean blood sugar levels determined found in Group I was 114.56 ± 10.39 and Group II was 86.24 ± 6.74, the p values in both groups were found to be significant. Similarly, the serum triglyceride levels in Group I was 181.96 ± 11.3 and Group II 4.9 ± 0.57, High Sensitive C reactive protein hs-CRP was 6.06 ± 0.61 in Group I and 2.19 ± 0.27 the p value was found to be significant.In the present study we found that CRP levels were significantly increased in the subjects with metabolic syndrome. Low-grade inflammatory markers like CRP are important parameters in the prediction of risk for development of insulin resistance and obesity. In fact the relation of CRP with metabolic syndrome is like a chain reaction one leads to increase in the other, thus leading to the formation of vicious cycle. Therefore levels CRP can predict the future development of metabolic syndrome and cardiovascular risk in this group of the population. Keywords:C Reactive Protein [CRP], metabolic syndrome [MS]
Authors and Affiliations
K. Prashanth
Keywords
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